Release and bioactivity of PACA nanoparticles containing D-Lys6-GnRH for brushtail possum fertility control

Research output: Contribution to journalJournal articleResearchpeer-review

Poly(ethylcyanoacrylate) (PECA) nanoparticles containing the chemical sterilitant D-Lys6-GnRH were prepared by an in situ interfacial polymerization technique. Their potential as a peroral delivery system for biocontrol of the brushtail possum, a major pest species in New Zealand, was evaluated. Peptide release from resulting particles was studied in vitro in artificial gastric juice (AGJ), simulated intestinal fluids (SIF) and brushtail possum plasma. The nanoparticles released a small fraction of bioactive over 6h in AGJ and SIF (
Original languageEnglish
JournalJournal of controlled release : official journal of the Controlled Release Society
Issue number3
Pages (from-to)307-13
Number of pages7
Publication statusPublished - 2011
Externally publishedYes

ID: 40343426