Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy

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At the example of carbamazepine the crystallization of a small organic molecule from its amorphous phase was studied using in situ variable temperature terahertz pulsed spectroscopy (TPS). Even though terahertz spectra of disordered materials in the glassy state exhibit no distinct spectral features we demonstrate subtle changes in the spectra with increasing temperature and discuss the findings in respect to the density of vibrational states. The crystallization leads to distinct spectral features allowing the crystallization and subsequent polymorphic phase transition at higher temperatures to be studied in detail. It is possible to study both relaxation and crystallization processes by variable temperature TPS.
Original languageEnglish
JournalJournal of Pharmaceutical Sciences
Issue number10
Pages (from-to)2703-9
Number of pages7
Publication statusPublished - 2007

    Research areas

  • Anticonvulsants, Carbamazepine, Crystallization, Models, Chemical, Phase Transition, Spectroscopy, Fourier Transform Infrared, Technology, Pharmaceutical, Transition Temperature, Vibration

ID: 40354287