Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles

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Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles. / Yaghmur, Anan; Mu, Huiling.

In: Acta Pharmaceutica Sinica B (Online), Vol. 11, No. 4, 04.2021, p. 871-885.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Yaghmur, A & Mu, H 2021, 'Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles', Acta Pharmaceutica Sinica B (Online), vol. 11, no. 4, pp. 871-885. https://doi.org/10.1016/j.apsb.2021.02.013

APA

Yaghmur, A., & Mu, H. (2021). Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles. Acta Pharmaceutica Sinica B (Online), 11(4), 871-885. https://doi.org/10.1016/j.apsb.2021.02.013

Vancouver

Yaghmur A, Mu H. Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles. Acta Pharmaceutica Sinica B (Online). 2021 Apr;11(4):871-885. https://doi.org/10.1016/j.apsb.2021.02.013

Author

Yaghmur, Anan ; Mu, Huiling. / Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles. In: Acta Pharmaceutica Sinica B (Online). 2021 ; Vol. 11, No. 4. pp. 871-885.

Bibtex

@article{b2954838b28e441aab9acc004da45d9b,

title = "Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles",

abstract = "The use of lipid nanocarriers for drug delivery applications is an active research area, and a great interest has particularly been shown in the past two decades. Among different lipid nanocarriers, ISAsomes (Internally self-assembled somes or particles), including cubosomes and hexosomes, and solid lipid nanoparticles (SLNs) have unique structural features, making them attractive as nanocarriers for drug delivery. In this contribution, we focus exclusively on recent advances in formation and characterization of ISAsomes, mainly cubosomes and hexosomes, and their use as versatile nanocarriers for different drug delivery applications. Additionally, the advantages of SLNs and their application in oral and pulmonary drug delivery are discussed with focus on the biological fates of these lipid nanocarriers in vivo. Despite the demonstrated advantages in in vitro and in vivo evaluations including preclinical studies, further investigations on improved understanding of the interactions of these nanoparticles with biological fluids and tissues of the target sites is necessary for efficient designing of drug nanocarriers and exploring potential clinical applications.",

author = "Anan Yaghmur and Huiling Mu",

note = "{\textcopyright} 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.",

year = "2021",

month = apr,

doi = "10.1016/j.apsb.2021.02.013",

language = "English",

volume = "11",

pages = "871--885",

journal = "Acta Pharmaceutica Sinica B (Online)",

issn = "2211-3843",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - Recent advances in drug delivery applications of cubosomes, hexosomes, and solid lipid nanoparticles

AU - Yaghmur, Anan

AU - Mu, Huiling

PY - 2021/4

Y1 - 2021/4

N2 - The use of lipid nanocarriers for drug delivery applications is an active research area, and a great interest has particularly been shown in the past two decades. Among different lipid nanocarriers, ISAsomes (Internally self-assembled somes or particles), including cubosomes and hexosomes, and solid lipid nanoparticles (SLNs) have unique structural features, making them attractive as nanocarriers for drug delivery. In this contribution, we focus exclusively on recent advances in formation and characterization of ISAsomes, mainly cubosomes and hexosomes, and their use as versatile nanocarriers for different drug delivery applications. Additionally, the advantages of SLNs and their application in oral and pulmonary drug delivery are discussed with focus on the biological fates of these lipid nanocarriers in vivo. Despite the demonstrated advantages in in vitro and in vivo evaluations including preclinical studies, further investigations on improved understanding of the interactions of these nanoparticles with biological fluids and tissues of the target sites is necessary for efficient designing of drug nanocarriers and exploring potential clinical applications.

AB - The use of lipid nanocarriers for drug delivery applications is an active research area, and a great interest has particularly been shown in the past two decades. Among different lipid nanocarriers, ISAsomes (Internally self-assembled somes or particles), including cubosomes and hexosomes, and solid lipid nanoparticles (SLNs) have unique structural features, making them attractive as nanocarriers for drug delivery. In this contribution, we focus exclusively on recent advances in formation and characterization of ISAsomes, mainly cubosomes and hexosomes, and their use as versatile nanocarriers for different drug delivery applications. Additionally, the advantages of SLNs and their application in oral and pulmonary drug delivery are discussed with focus on the biological fates of these lipid nanocarriers in vivo. Despite the demonstrated advantages in in vitro and in vivo evaluations including preclinical studies, further investigations on improved understanding of the interactions of these nanoparticles with biological fluids and tissues of the target sites is necessary for efficient designing of drug nanocarriers and exploring potential clinical applications.

U2 - 10.1016/j.apsb.2021.02.013

DO - 10.1016/j.apsb.2021.02.013

M3 - Review

C2 - 33996404

VL - 11

SP - 871

EP - 885

JO - Acta Pharmaceutica Sinica B (Online)

JF - Acta Pharmaceutica Sinica B (Online)

SN - 2211-3843

IS - 4

ER -

ID: 272322575

Department of Pharmacy