Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections
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Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections. / Akay, Seref; Yaghmur, Anan.
In: Molecules, Vol. 29, No. 5, 1172, 2024.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections
AU - Akay, Seref
AU - Yaghmur, Anan
N1 - Publisher Copyright: © 2024 by the authors.
PY - 2024
Y1 - 2024
N2 - Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on medical implants are surgical operations and long-term and repeated antibiotic courses. Recent years have witnessed a growing interest in the development of robust and reliable strategies for prevention and treatment of IAIs. In particular, it seems promising to develop materials with anti-biofouling and antibacterial properties for combating IAIs on implants. In this contribution, we exclusively focus on recent advances in the development of modified and functionalized implant surfaces for inhibiting bacterial attachment and eventually biofilm formation on orthopedic implants. Further, we highlight recent progress in the development of antibacterial coatings (including self-assembled nanocoatings) for preventing biofilm formation on orthopedic implants. Among the recently introduced approaches for development of efficient and durable antibacterial coatings, we focus on the use of safe and biocompatible materials with excellent antibacterial activities for local delivery of combinatorial antimicrobial agents for preventing and treating IAIs and overcoming antimicrobial resistance.
AB - Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on medical implants are surgical operations and long-term and repeated antibiotic courses. Recent years have witnessed a growing interest in the development of robust and reliable strategies for prevention and treatment of IAIs. In particular, it seems promising to develop materials with anti-biofouling and antibacterial properties for combating IAIs on implants. In this contribution, we exclusively focus on recent advances in the development of modified and functionalized implant surfaces for inhibiting bacterial attachment and eventually biofilm formation on orthopedic implants. Further, we highlight recent progress in the development of antibacterial coatings (including self-assembled nanocoatings) for preventing biofilm formation on orthopedic implants. Among the recently introduced approaches for development of efficient and durable antibacterial coatings, we focus on the use of safe and biocompatible materials with excellent antibacterial activities for local delivery of combinatorial antimicrobial agents for preventing and treating IAIs and overcoming antimicrobial resistance.
KW - antibacterial
KW - biofilm
KW - infections
KW - local antimicrobial agent delivery
KW - lyotropic non-lamellar liquid crystalline phases
KW - orthopedic implants
KW - polymeric coatings
U2 - 10.3390/molecules29051172
DO - 10.3390/molecules29051172
M3 - Review
C2 - 38474684
AN - SCOPUS:85187786138
VL - 29
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 5
M1 - 1172
ER -
ID: 387021260