Rapid Prototyping of Miniaturized Powder Mixing Geometries

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Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.

Original languageEnglish
JournalJournal of Pharmaceutical Sciences
Issue number7
Pages (from-to)2625-2628
Publication statusPublished - 2021

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Publisher Copyright:
© 2021 The Authors

    Research areas

  • 3D printing, Continuous manufacturing, Inline monitoring, Multivariate data analysis, Process analytical technology (PAT), Residence time distribution (RTD)

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