Rapid Prototyping of Miniaturized Powder Mixing Geometries
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Rapid Prototyping of Miniaturized Powder Mixing Geometries. / Svane, Rasmus; Pedersen, Troels; Hirschberg, Cosima; Rantanen, Jukka.
In: Journal of Pharmaceutical Sciences, Vol. 110, No. 7, 2021, p. 2625-2628.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Rapid Prototyping of Miniaturized Powder Mixing Geometries
AU - Svane, Rasmus
AU - Pedersen, Troels
AU - Hirschberg, Cosima
AU - Rantanen, Jukka
N1 - Publisher Copyright: © 2021 The Authors
PY - 2021
Y1 - 2021
N2 - Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.
AB - Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.
KW - 3D printing
KW - Continuous manufacturing
KW - Inline monitoring
KW - Multivariate data analysis
KW - Process analytical technology (PAT)
KW - Residence time distribution (RTD)
U2 - 10.1016/j.xphs.2021.03.019
DO - 10.1016/j.xphs.2021.03.019
M3 - Journal article
C2 - 33775671
AN - SCOPUS:85109057218
VL - 110
SP - 2625
EP - 2628
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 7
ER -
ID: 279127580