Polyester based nanovehicles for siRNA delivery

Research output: Contribution to journal › Review › Research › peer-review

Standard

Polyester based nanovehicles for siRNA delivery. / Xu, Zejun; Wang, Danyang; Cheng, Yanqin; Yang, Mingshi; Wu, Lin-Ping.

In: Materials Science and Engineering C: Materials for Biological Applications, Vol. 92, 2018, p. 1006-1015.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Xu, Z, Wang, D, Cheng, Y, Yang, M & Wu, L-P 2018, 'Polyester based nanovehicles for siRNA delivery', Materials Science and Engineering C: Materials for Biological Applications, vol. 92, pp. 1006-1015. https://doi.org/10.1016/j.msec.2018.05.031

APA

Xu, Z., Wang, D., Cheng, Y., Yang, M., & Wu, L-P. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C: Materials for Biological Applications, 92, 1006-1015. https://doi.org/10.1016/j.msec.2018.05.031

Vancouver

Xu Z, Wang D, Cheng Y, Yang M, Wu L-P. Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C: Materials for Biological Applications. 2018;92:1006-1015. https://doi.org/10.1016/j.msec.2018.05.031

Author

Xu, Zejun ; Wang, Danyang ; Cheng, Yanqin ; Yang, Mingshi ; Wu, Lin-Ping. / Polyester based nanovehicles for siRNA delivery. In: Materials Science and Engineering C: Materials for Biological Applications. 2018 ; Vol. 92. pp. 1006-1015.

Bibtex

@article{ced78109a2fb4a8895e0b80f2d6c9825,

title = "Polyester based nanovehicles for siRNA delivery",

abstract = "Small interfering RNA (siRNA) has potential as therapeutic agents against various diseases because it can reversibly silence any gene with high efficiency and specificity. Unmodified siRNA is a hydrophilic molecule with negative charge, which is unstable in the bloodstream and cannot freely cross cell membranes. Therefore, the safe and effective delivery systems are necessary to achieve siRNA-based therapeutics. This review will summarize the polyester nanovehicles which are being employed to deliver siRNA, mainly including poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), polycaprolactone (PCL) and some other polyesters. The characteristics of these polyester nanovehicles including their structural properties and functional modifications will be thoroughly demonstrated, which is intended to improve the therapeutic effects of siRNA.",

author = "Zejun Xu and Danyang Wang and Yanqin Cheng and Mingshi Yang and Lin-Ping Wu",

year = "2018",

doi = "10.1016/j.msec.2018.05.031",

language = "English",

volume = "92",

pages = "1006--1015",

journal = "Materials Science and Engineering C: Materials for Biological Applications",

issn = "1873-0191",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Polyester based nanovehicles for siRNA delivery

AU - Xu, Zejun

AU - Wang, Danyang

AU - Cheng, Yanqin

AU - Yang, Mingshi

AU - Wu, Lin-Ping

PY - 2018

Y1 - 2018

N2 - Small interfering RNA (siRNA) has potential as therapeutic agents against various diseases because it can reversibly silence any gene with high efficiency and specificity. Unmodified siRNA is a hydrophilic molecule with negative charge, which is unstable in the bloodstream and cannot freely cross cell membranes. Therefore, the safe and effective delivery systems are necessary to achieve siRNA-based therapeutics. This review will summarize the polyester nanovehicles which are being employed to deliver siRNA, mainly including poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), polycaprolactone (PCL) and some other polyesters. The characteristics of these polyester nanovehicles including their structural properties and functional modifications will be thoroughly demonstrated, which is intended to improve the therapeutic effects of siRNA.

AB - Small interfering RNA (siRNA) has potential as therapeutic agents against various diseases because it can reversibly silence any gene with high efficiency and specificity. Unmodified siRNA is a hydrophilic molecule with negative charge, which is unstable in the bloodstream and cannot freely cross cell membranes. Therefore, the safe and effective delivery systems are necessary to achieve siRNA-based therapeutics. This review will summarize the polyester nanovehicles which are being employed to deliver siRNA, mainly including poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), polycaprolactone (PCL) and some other polyesters. The characteristics of these polyester nanovehicles including their structural properties and functional modifications will be thoroughly demonstrated, which is intended to improve the therapeutic effects of siRNA.

U2 - 10.1016/j.msec.2018.05.031

DO - 10.1016/j.msec.2018.05.031

M3 - Review

C2 - 30184724

VL - 92

SP - 1006

EP - 1015

JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

SN - 1873-0191

ER -

ID: 202386385