On-chip electromembrane extraction of acidic drugs
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On-chip electromembrane extraction of acidic drugs. / Roman-Hidalgo, Cristina; Santigosa-Murillo, Elia; Ramos-Payán, María; Petersen, Nickolaj J.; Kutter, Jörg P.; Pedersen-Bjergaard, Stig.
In: Electrophoresis, Vol. 40, No. 18-19, 2019, p. 2514-2521.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - On-chip electromembrane extraction of acidic drugs
AU - Roman-Hidalgo, Cristina
AU - Santigosa-Murillo, Elia
AU - Ramos-Payán, María
AU - Petersen, Nickolaj J.
AU - Kutter, Jörg P.
AU - Pedersen-Bjergaard, Stig
PY - 2019
Y1 - 2019
N2 - In the present work, a new supported liquid membrane (SLM) has been developed for on-chip electromembrane extraction of acidic drugs combined with HPLC or CE, providing significantly higher stability than those reported up to date. The target analytes are five widely used non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), diclofenac (DIC), naproxen (NAX), ketoprofen (KTP) and salicylic acid (SAL). Two different microchip devices were used, both consisted basically of two poly(methyl methacrylate) (PMMA) plates with individual channels for acceptor and sample solutions, respectively, and a 25 µm thick porous polypropylene membrane impregnated with the organic solvent in between. The SLM consisting of a mixture of 1-undecanol and 2-nitrophenyl octyl ether (NPOE) in a ratio 1:3 was found to be the most suitable liquid membrane for the extraction of these acidic drugs under dynamic conditions. It showed a long-term stability of at least 8 hours, a low system current around 20 µA, and recoveries over 94% for the target analytes. NPOE was included in the SLM to significantly decrease the extraction current compared to pure 1-undecanol, while the extraction properties was almost unaffected. Moreover, it has been successfully applied to the determination of the target analytes in human urine samples, providing high extraction efficiency.
AB - In the present work, a new supported liquid membrane (SLM) has been developed for on-chip electromembrane extraction of acidic drugs combined with HPLC or CE, providing significantly higher stability than those reported up to date. The target analytes are five widely used non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), diclofenac (DIC), naproxen (NAX), ketoprofen (KTP) and salicylic acid (SAL). Two different microchip devices were used, both consisted basically of two poly(methyl methacrylate) (PMMA) plates with individual channels for acceptor and sample solutions, respectively, and a 25 µm thick porous polypropylene membrane impregnated with the organic solvent in between. The SLM consisting of a mixture of 1-undecanol and 2-nitrophenyl octyl ether (NPOE) in a ratio 1:3 was found to be the most suitable liquid membrane for the extraction of these acidic drugs under dynamic conditions. It showed a long-term stability of at least 8 hours, a low system current around 20 µA, and recoveries over 94% for the target analytes. NPOE was included in the SLM to significantly decrease the extraction current compared to pure 1-undecanol, while the extraction properties was almost unaffected. Moreover, it has been successfully applied to the determination of the target analytes in human urine samples, providing high extraction efficiency.
KW - Acid drugs
KW - Electromembrane extraction
KW - Microchip
KW - Urine samples
U2 - 10.1002/elps.201900024
DO - 10.1002/elps.201900024
M3 - Journal article
C2 - 30916800
AN - SCOPUS:85063724298
VL - 40
SP - 2514
EP - 2521
JO - Electrophoresis
JF - Electrophoresis
SN - 0173-0835
IS - 18-19
ER -
ID: 241051486