Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. / Zhong, Shuncong; Shen, Yao Chun; Ho, Louise; May, Robert K.; Zeitler, J. Axel; Evans, Mike; Taday, Philip F.; Pepper, Michael; Rades, Thomas; Gordon, Keith C.; Mller, Ronny; Kleinebudde, Peter.

In: Optics and Lasers in Engineering, Vol. 49, No. 3, 03.2011, p. 361-365.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhong, S, Shen, YC, Ho, L, May, RK, Zeitler, JA, Evans, M, Taday, PF, Pepper, M, Rades, T, Gordon, KC, Mller, R & Kleinebudde, P 2011, 'Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography', Optics and Lasers in Engineering, vol. 49, no. 3, pp. 361-365. https://doi.org/10.1016/j.optlaseng.2010.11.003

APA

Zhong, S., Shen, Y. C., Ho, L., May, R. K., Zeitler, J. A., Evans, M., Taday, P. F., Pepper, M., Rades, T., Gordon, K. C., Mller, R., & Kleinebudde, P. (2011). Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. Optics and Lasers in Engineering, 49(3), 361-365. https://doi.org/10.1016/j.optlaseng.2010.11.003

Vancouver

Zhong S, Shen YC, Ho L, May RK, Zeitler JA, Evans M et al. Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. Optics and Lasers in Engineering. 2011 Mar;49(3):361-365. https://doi.org/10.1016/j.optlaseng.2010.11.003

Author

Zhong, Shuncong ; Shen, Yao Chun ; Ho, Louise ; May, Robert K. ; Zeitler, J. Axel ; Evans, Mike ; Taday, Philip F. ; Pepper, Michael ; Rades, Thomas ; Gordon, Keith C. ; Mller, Ronny ; Kleinebudde, Peter. / Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. In: Optics and Lasers in Engineering. 2011 ; Vol. 49, No. 3. pp. 361-365.

Bibtex

@article{d2d6b7c68027429bb0c160d3778d6841,
title = "Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography",
abstract = "Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10140 μm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 μm, and is capable of quantifying very thin coatings in the range of 1060 μm. The upper limit of 60 μm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.51.0 μm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40140 μm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings.",
keywords = "Non-destructive testing, Optical coherence tomography, Tablet coating thickness, Terahertz pulsed imaging",
author = "Shuncong Zhong and Shen, {Yao Chun} and Louise Ho and May, {Robert K.} and Zeitler, {J. Axel} and Mike Evans and Taday, {Philip F.} and Michael Pepper and Thomas Rades and Gordon, {Keith C.} and Ronny Mller and Peter Kleinebudde",
note = "Funding Information: The authors would like to acknowledge the financial support from UK Technology Strategy Board ( AB293H ). S. Zhong would like to thank Fuzhou University Research Fund, Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, P.R. China, and National Natural Science Foundation of China ( 51005077 ).",
year = "2011",
month = mar,
doi = "10.1016/j.optlaseng.2010.11.003",
language = "English",
volume = "49",
pages = "361--365",
journal = "Optics and Lasers in Engineering",
issn = "0143-8166",
publisher = "Elsevier Limited",
number = "3",

}

RIS

TY - JOUR

T1 - Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

AU - Zhong, Shuncong

AU - Shen, Yao Chun

AU - Ho, Louise

AU - May, Robert K.

AU - Zeitler, J. Axel

AU - Evans, Mike

AU - Taday, Philip F.

AU - Pepper, Michael

AU - Rades, Thomas

AU - Gordon, Keith C.

AU - Mller, Ronny

AU - Kleinebudde, Peter

N1 - Funding Information: The authors would like to acknowledge the financial support from UK Technology Strategy Board ( AB293H ). S. Zhong would like to thank Fuzhou University Research Fund, Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, P.R. China, and National Natural Science Foundation of China ( 51005077 ).

PY - 2011/3

Y1 - 2011/3

N2 - Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10140 μm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 μm, and is capable of quantifying very thin coatings in the range of 1060 μm. The upper limit of 60 μm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.51.0 μm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40140 μm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings.

AB - Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10140 μm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 μm, and is capable of quantifying very thin coatings in the range of 1060 μm. The upper limit of 60 μm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.51.0 μm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40140 μm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings.

KW - Non-destructive testing

KW - Optical coherence tomography

KW - Tablet coating thickness

KW - Terahertz pulsed imaging

UR - http://www.scopus.com/inward/record.url?scp=78650829757&partnerID=8YFLogxK

U2 - 10.1016/j.optlaseng.2010.11.003

DO - 10.1016/j.optlaseng.2010.11.003

M3 - Journal article

AN - SCOPUS:78650829757

VL - 49

SP - 361

EP - 365

JO - Optics and Lasers in Engineering

JF - Optics and Lasers in Engineering

SN - 0143-8166

IS - 3

ER -

ID: 299416402