Nanoparticles for mucosal vaccine delivery
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Standard
Nanoparticles for mucosal vaccine delivery. / Thakur, Aneesh; Foged, Camilla.
Nanoengineered Biomaterials for Advanced Drug Delivery. Woodhead Publishing, 2020. p. 603-646.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - CHAP
T1 - Nanoparticles for mucosal vaccine delivery
AU - Thakur, Aneesh
AU - Foged, Camilla
N1 - Publisher Copyright: © 2020 Elsevier Ltd All rights reserved.
PY - 2020
Y1 - 2020
N2 - Mucosal surfaces represent important routes of entry into the human body for the majority of pathogens, and they constitute unique sites for targeted vaccine delivery. Nanoparticle-based drug delivery systems are emerging technologies for delivering and improving the efficacy of mucosal vaccines. Recent studies have provided new insights into formulation and delivery aspects of importance for the design of safe and efficacious mucosal subunit vaccines based on nanoparticles. These include novel nanomaterials, their physicochemical properties and formulation approaches, nanoparticle interaction with immune cells in the mucosa, and mucosal immunization and delivery strategies. Here, we present recent progress in the application of nanoparticle-based approaches for mucosal vaccine delivery and discuss future research challenges and opportunities in the field.
AB - Mucosal surfaces represent important routes of entry into the human body for the majority of pathogens, and they constitute unique sites for targeted vaccine delivery. Nanoparticle-based drug delivery systems are emerging technologies for delivering and improving the efficacy of mucosal vaccines. Recent studies have provided new insights into formulation and delivery aspects of importance for the design of safe and efficacious mucosal subunit vaccines based on nanoparticles. These include novel nanomaterials, their physicochemical properties and formulation approaches, nanoparticle interaction with immune cells in the mucosa, and mucosal immunization and delivery strategies. Here, we present recent progress in the application of nanoparticle-based approaches for mucosal vaccine delivery and discuss future research challenges and opportunities in the field.
KW - Adjuvants
KW - Drug delivery
KW - Mucosal immunization
KW - Nanoparticles
KW - Vaccines
U2 - 10.1016/B978-0-08-102985-5.00025-5
DO - 10.1016/B978-0-08-102985-5.00025-5
M3 - Book chapter
AN - SCOPUS:85096934998
SP - 603
EP - 646
BT - Nanoengineered Biomaterials for Advanced Drug Delivery
PB - Woodhead Publishing
ER -
ID: 299271932