Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis
Research output: Contribution to journal › Journal article › Research › peer-review
Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.
|Journal||Angewandte Chemie (International ed. in English)|
|Number of pages||5|
|Publication status||Published - 27 Mar 2017|
- Journal Article