Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis

Research output: Contribution to journalJournal articleResearchpeer-review

  • Maksymilian Kurek
  • Matthias Carnoy
  • Peter E Larsen
  • Line H Nielsen
  • Ole Hansen
  • Rades, Thomas
  • Silvan Schmid
  • Anja Boisen

Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.

Original languageEnglish
JournalAngewandte Chemie (International ed. in English)
Issue number14
Pages (from-to)3901-3905
Number of pages5
Publication statusPublished - 27 Mar 2017

    Research areas

  • Journal Article

ID: 185437793