N-acylation of phosphatidylethanolamine and its biological functions in mammals

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N-acylation of phosphatidylethanolamine and its biological functions in mammals. / Wellner, Niels; Diep, Thi Ai; Janfelt, Christian; Hansen, Harald Severin.

In: BBA General Subjects, Vol. 1831, No. 3, 03.2013, p. 652-62.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wellner, N, Diep, TA, Janfelt, C & Hansen, HS 2013, 'N-acylation of phosphatidylethanolamine and its biological functions in mammals', BBA General Subjects, vol. 1831, no. 3, pp. 652-62. https://doi.org/10.1016/j.bbalip.2012.08.019

APA

Wellner, N., Diep, T. A., Janfelt, C., & Hansen, H. S. (2013). N-acylation of phosphatidylethanolamine and its biological functions in mammals. BBA General Subjects, 1831(3), 652-62. https://doi.org/10.1016/j.bbalip.2012.08.019

Vancouver

Wellner N, Diep TA, Janfelt C, Hansen HS. N-acylation of phosphatidylethanolamine and its biological functions in mammals. BBA General Subjects. 2013 Mar;1831(3):652-62. https://doi.org/10.1016/j.bbalip.2012.08.019

Author

Wellner, Niels ; Diep, Thi Ai ; Janfelt, Christian ; Hansen, Harald Severin. / N-acylation of phosphatidylethanolamine and its biological functions in mammals. In: BBA General Subjects. 2013 ; Vol. 1831, No. 3. pp. 652-62.

Bibtex

@article{6006ec2a28994baa942771beeec4135d,

title = "N-acylation of phosphatidylethanolamine and its biological functions in mammals",

abstract = "N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain ischemia, and to modulate food intake in rodents, thus having bioactive effects besides its precursor role. This paper reviews the metabolism, occurrence and assay of NAPE and pNAPE, and discusses the putative biological functions in mammals of these phospholipids. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.",

keywords = "Acylation, Animals, Appetite Regulation, Arachidonic Acids, Brain, Endocannabinoids, Ethanolamines, Humans, Lysosomes, Phosphatidylethanolamines, Phospholipase D, Polyunsaturated Alkamides, Rodentia, Signal Transduction, Type C Phospholipases",

author = "Niels Wellner and Diep, {Thi Ai} and Christian Janfelt and Hansen, {Harald Severin}",

year = "2013",

month = mar,

doi = "10.1016/j.bbalip.2012.08.019",

language = "English",

volume = "1831",

pages = "652--62",

journal = "B B A - General Subjects",

issn = "0304-4165",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - N-acylation of phosphatidylethanolamine and its biological functions in mammals

AU - Wellner, Niels

AU - Diep, Thi Ai

AU - Janfelt, Christian

AU - Hansen, Harald Severin

PY - 2013/3

Y1 - 2013/3

N2 - N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain ischemia, and to modulate food intake in rodents, thus having bioactive effects besides its precursor role. This paper reviews the metabolism, occurrence and assay of NAPE and pNAPE, and discusses the putative biological functions in mammals of these phospholipids. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.

AB - N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain ischemia, and to modulate food intake in rodents, thus having bioactive effects besides its precursor role. This paper reviews the metabolism, occurrence and assay of NAPE and pNAPE, and discusses the putative biological functions in mammals of these phospholipids. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.

KW - Acylation

KW - Animals

KW - Appetite Regulation

KW - Arachidonic Acids

KW - Brain

KW - Endocannabinoids

KW - Ethanolamines

KW - Humans

KW - Lysosomes

KW - Phosphatidylethanolamines

KW - Phospholipase D

KW - Polyunsaturated Alkamides

KW - Rodentia

KW - Signal Transduction

KW - Type C Phospholipases

U2 - 10.1016/j.bbalip.2012.08.019

DO - 10.1016/j.bbalip.2012.08.019

M3 - Journal article

C2 - 23000428

VL - 1831

SP - 652

EP - 662

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 3

ER -

ID: 45155326

Department of Pharmacy