Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging

Research output: Contribution to journalJournal articlepeer-review

Standard

Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging. / Ostergaard, Jesper; Ye, Fengbin; Rantanen, Jukka; Yaghmur, Anan; Larsen, Susan Weng; Larsen, Claus Selch; Jensen, Henrik.

In: Journal of Pharmaceutical Sciences, Vol. 100, No. 8, 08.2011, p. 3405-3410.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ostergaard, J, Ye, F, Rantanen, J, Yaghmur, A, Larsen, SW, Larsen, CS & Jensen, H 2011, 'Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging', Journal of Pharmaceutical Sciences, vol. 100, no. 8, pp. 3405-3410. https://doi.org/10.1002/jps.22532

APA

Ostergaard, J., Ye, F., Rantanen, J., Yaghmur, A., Larsen, S. W., Larsen, C. S., & Jensen, H. (2011). Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging. Journal of Pharmaceutical Sciences, 100(8), 3405-3410. https://doi.org/10.1002/jps.22532

Vancouver

Ostergaard J, Ye F, Rantanen J, Yaghmur A, Larsen SW, Larsen CS et al. Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging. Journal of Pharmaceutical Sciences. 2011 Aug;100(8):3405-3410. https://doi.org/10.1002/jps.22532

Author

Ostergaard, Jesper ; Ye, Fengbin ; Rantanen, Jukka ; Yaghmur, Anan ; Larsen, Susan Weng ; Larsen, Claus Selch ; Jensen, Henrik. / Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging. In: Journal of Pharmaceutical Sciences. 2011 ; Vol. 100, No. 8. pp. 3405-3410.

Bibtex

@article{e65c03d82bb047838405775391007ec4,
title = "Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging",
abstract = "Dissolution critically affects the bioavailability of Biopharmaceutics Classification System class 2 compounds. When unexpected dissolution behaviour occurs, detailed studies using high information content technologies are warranted. In the present study, an evaluation of real‐time ultraviolet (UV) imaging for conducting single‐crystal dissolution studies was performed. Using lidocaine as a model compound, the aim was to develop a setup capable of monitoring and quantifying the dissolution of lidocaine into a phosphate buffer, pH 7.4, under stagnant conditions. A single crystal of lidocaine was placed in the quartz dissolution cell and UV imaging was performed at 254 nm. Spatially and temporally resolved mapping of lidocaine concentration during the dissolution process was achieved from the recorded images. UV imaging facilitated the monitoring of lidocaine concentrations in the dissolution media adjacent to the single crystals. The concentration maps revealed the effects of natural convection due to density gradients on the dissolution process of lidocaine. UV imaging has great potential for in vitro drug dissolution testing",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Jesper Ostergaard and Fengbin Ye and Jukka Rantanen and Anan Yaghmur and Larsen, {Susan Weng} and Larsen, {Claus Selch} and Henrik Jensen",
year = "2011",
month = aug,
doi = "10.1002/jps.22532",
language = "English",
volume = "100",
pages = "3405--3410",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Monitoring Lidocaine Single-Crystal Dissolution by Ultraviolet Imaging

AU - Ostergaard, Jesper

AU - Ye, Fengbin

AU - Rantanen, Jukka

AU - Yaghmur, Anan

AU - Larsen, Susan Weng

AU - Larsen, Claus Selch

AU - Jensen, Henrik

PY - 2011/8

Y1 - 2011/8

N2 - Dissolution critically affects the bioavailability of Biopharmaceutics Classification System class 2 compounds. When unexpected dissolution behaviour occurs, detailed studies using high information content technologies are warranted. In the present study, an evaluation of real‐time ultraviolet (UV) imaging for conducting single‐crystal dissolution studies was performed. Using lidocaine as a model compound, the aim was to develop a setup capable of monitoring and quantifying the dissolution of lidocaine into a phosphate buffer, pH 7.4, under stagnant conditions. A single crystal of lidocaine was placed in the quartz dissolution cell and UV imaging was performed at 254 nm. Spatially and temporally resolved mapping of lidocaine concentration during the dissolution process was achieved from the recorded images. UV imaging facilitated the monitoring of lidocaine concentrations in the dissolution media adjacent to the single crystals. The concentration maps revealed the effects of natural convection due to density gradients on the dissolution process of lidocaine. UV imaging has great potential for in vitro drug dissolution testing

AB - Dissolution critically affects the bioavailability of Biopharmaceutics Classification System class 2 compounds. When unexpected dissolution behaviour occurs, detailed studies using high information content technologies are warranted. In the present study, an evaluation of real‐time ultraviolet (UV) imaging for conducting single‐crystal dissolution studies was performed. Using lidocaine as a model compound, the aim was to develop a setup capable of monitoring and quantifying the dissolution of lidocaine into a phosphate buffer, pH 7.4, under stagnant conditions. A single crystal of lidocaine was placed in the quartz dissolution cell and UV imaging was performed at 254 nm. Spatially and temporally resolved mapping of lidocaine concentration during the dissolution process was achieved from the recorded images. UV imaging facilitated the monitoring of lidocaine concentrations in the dissolution media adjacent to the single crystals. The concentration maps revealed the effects of natural convection due to density gradients on the dissolution process of lidocaine. UV imaging has great potential for in vitro drug dissolution testing

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/jps.22532

DO - 10.1002/jps.22532

M3 - Journal article

C2 - 21387316

VL - 100

SP - 3405

EP - 3410

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 8

ER -

ID: 33619222