Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine. / Xu, Xiaoyue; Rades, Thomas; Grohganz, Holger.

In: International Journal of Pharmaceutics, Vol. 651, 123807, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Xu, X, Rades, T & Grohganz, H 2024, 'Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine', International Journal of Pharmaceutics, vol. 651, 123807. https://doi.org/10.1016/j.ijpharm.2024.123807

APA

Xu, X., Rades, T., & Grohganz, H. (2024). Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine. International Journal of Pharmaceutics, 651, [123807]. https://doi.org/10.1016/j.ijpharm.2024.123807

Vancouver

Xu X, Rades T, Grohganz H. Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine. International Journal of Pharmaceutics. 2024;651. 123807. https://doi.org/10.1016/j.ijpharm.2024.123807

Author

Xu, Xiaoyue ; Rades, Thomas ; Grohganz, Holger. / Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine. In: International Journal of Pharmaceutics. 2024 ; Vol. 651.

Bibtex

@article{92ef660efb544b4bb417662c079b0dc3,
title = "Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine",
abstract = "It is generally accepted that water as a plasticizer can decrease the glass transition temperatures (Tgs) of amorphous drugs and drug excipient systems. However, previous studies suggest that water, as an anti-plasticizer, can increase the Tgs of co-amorphous systems of prilocaine (PRL) and lidocaine (LID). In order to investigate the intermolecular interactions between water and co-amorphous PRL-LID systems, Fourier transform infrared spectroscopy (FTIR) and principal component analysis (PCA) were conducted. Water was found to bind with the carbonyl groups of PRL and LID molecularly evenly in the hydrated co-amorphous PRL-LID systems. Quantum chemical simulations visually confirmed the interactions between water and co-amorphous PRL-LID systems. Furthermore, the physical stability of hydrated co-amorphous PRL-LID systems was improved due to the anti-plasticizing effect of water, compared with the anhydrous samples. The preference of water to interact with the carbonyl groups of PRL and LID as binding sites could be associated with the anti-plasticizing effect of water on the co-amorphous PRL-LID systems.",
keywords = "Anti-plasticizing, Co-amorphous, Effect of water, Lidocaine, Molecular interactions, Prilocaine",
author = "Xiaoyue Xu and Thomas Rades and Holger Grohganz",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",
year = "2024",
doi = "10.1016/j.ijpharm.2024.123807",
language = "English",
volume = "651",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Molecular interactions of hydrated co-amorphous systems of prilocaine and lidocaine

AU - Xu, Xiaoyue

AU - Rades, Thomas

AU - Grohganz, Holger

N1 - Publisher Copyright: © 2024 The Author(s)

PY - 2024

Y1 - 2024

N2 - It is generally accepted that water as a plasticizer can decrease the glass transition temperatures (Tgs) of amorphous drugs and drug excipient systems. However, previous studies suggest that water, as an anti-plasticizer, can increase the Tgs of co-amorphous systems of prilocaine (PRL) and lidocaine (LID). In order to investigate the intermolecular interactions between water and co-amorphous PRL-LID systems, Fourier transform infrared spectroscopy (FTIR) and principal component analysis (PCA) were conducted. Water was found to bind with the carbonyl groups of PRL and LID molecularly evenly in the hydrated co-amorphous PRL-LID systems. Quantum chemical simulations visually confirmed the interactions between water and co-amorphous PRL-LID systems. Furthermore, the physical stability of hydrated co-amorphous PRL-LID systems was improved due to the anti-plasticizing effect of water, compared with the anhydrous samples. The preference of water to interact with the carbonyl groups of PRL and LID as binding sites could be associated with the anti-plasticizing effect of water on the co-amorphous PRL-LID systems.

AB - It is generally accepted that water as a plasticizer can decrease the glass transition temperatures (Tgs) of amorphous drugs and drug excipient systems. However, previous studies suggest that water, as an anti-plasticizer, can increase the Tgs of co-amorphous systems of prilocaine (PRL) and lidocaine (LID). In order to investigate the intermolecular interactions between water and co-amorphous PRL-LID systems, Fourier transform infrared spectroscopy (FTIR) and principal component analysis (PCA) were conducted. Water was found to bind with the carbonyl groups of PRL and LID molecularly evenly in the hydrated co-amorphous PRL-LID systems. Quantum chemical simulations visually confirmed the interactions between water and co-amorphous PRL-LID systems. Furthermore, the physical stability of hydrated co-amorphous PRL-LID systems was improved due to the anti-plasticizing effect of water, compared with the anhydrous samples. The preference of water to interact with the carbonyl groups of PRL and LID as binding sites could be associated with the anti-plasticizing effect of water on the co-amorphous PRL-LID systems.

KW - Anti-plasticizing

KW - Co-amorphous

KW - Effect of water

KW - Lidocaine

KW - Molecular interactions

KW - Prilocaine

U2 - 10.1016/j.ijpharm.2024.123807

DO - 10.1016/j.ijpharm.2024.123807

M3 - Journal article

C2 - 38220121

AN - SCOPUS:85183639849

VL - 651

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

M1 - 123807

ER -

ID: 382494964