Mesoporous silicas templated by heterocyclic amino acid derivatives: Biomimetic synthesis and drug release application

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mesoporous silicas templated by heterocyclic amino acid derivatives : Biomimetic synthesis and drug release application. / Li, Heran; Ke, Jia; Li, Haiting; Wei, Chen; Wu, Xueqian; Li, Jing; Yang, Yang; Xu, Lu; Liu, Hongzhuo; Li, Sanming; Yang, Mingshi; Wei, Minjei.

In: Materials Science and Engineering C, Vol. 93, 2018, p. 407-418.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, H, Ke, J, Li, H, Wei, C, Wu, X, Li, J, Yang, Y, Xu, L, Liu, H, Li, S, Yang, M & Wei, M 2018, 'Mesoporous silicas templated by heterocyclic amino acid derivatives: Biomimetic synthesis and drug release application', Materials Science and Engineering C, vol. 93, pp. 407-418. https://doi.org/10.1016/j.msec.2018.07.081

APA

Li, H., Ke, J., Li, H., Wei, C., Wu, X., Li, J., Yang, Y., Xu, L., Liu, H., Li, S., Yang, M., & Wei, M. (2018). Mesoporous silicas templated by heterocyclic amino acid derivatives: Biomimetic synthesis and drug release application. Materials Science and Engineering C, 93, 407-418. https://doi.org/10.1016/j.msec.2018.07.081

Vancouver

Li H, Ke J, Li H, Wei C, Wu X, Li J et al. Mesoporous silicas templated by heterocyclic amino acid derivatives: Biomimetic synthesis and drug release application. Materials Science and Engineering C. 2018;93:407-418. https://doi.org/10.1016/j.msec.2018.07.081

Author

Li, Heran ; Ke, Jia ; Li, Haiting ; Wei, Chen ; Wu, Xueqian ; Li, Jing ; Yang, Yang ; Xu, Lu ; Liu, Hongzhuo ; Li, Sanming ; Yang, Mingshi ; Wei, Minjei. / Mesoporous silicas templated by heterocyclic amino acid derivatives : Biomimetic synthesis and drug release application. In: Materials Science and Engineering C. 2018 ; Vol. 93. pp. 407-418.

Bibtex

@article{4bb226483f2e45bebb0a280c34b52b29,
title = "Mesoporous silicas templated by heterocyclic amino acid derivatives: Biomimetic synthesis and drug release application",
abstract = " The present paper reported a biomimetic synthesis of mesoporous silicas (BMSs) at room temperature by using synthesized polymers (C 16 -L-His, C 16 -L-Pro and C 16 -L-Trp) which derived from amino acid with ring structures as template under basic condition via co-structural-directing-agent method. The formation mechanism of BMSs and effect of initial synthesis conditions (such as surfactant structure, pH and co-solvents) on morphology and structure of BMSs were systematically studied. Synthesized BMSs were characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and nitrogen adsorption/desorption isotherms. The results showed that the surfactant structure was the dominant factor to direct the final mesostructure of BMSs, since the structure of surfactant affected the structure and size of clusters. Meanwhile the generation of BMSs required very rigorous alkaline condition which controlled the ionization degree of the surfactant and thus contributing to adequate stacking energy. Higher pH resulted in construction of channels with higher curvature. The presence of ethanol was found to facilitate the formation of BMSs with larger particle size. In application, aspirin can be loaded into BMSs with high efficiency, and the drug crystalline state of aspirin transformed from crystalline state to amorphous state during this process, which undoubtedly lead to the improvement of drug dissolution from 72.8% to 100% within 90 min. It is convincible that the biomimetic method presented here provided novel insight on precisely control of mesoporous silica and undoubtedly promoted the application of mesoporous silica materials. ",
keywords = "Biomimetic synthesis nanomaterial, Drug delivery, Dynamic self-assembly, Mesoporous silica",
author = "Heran Li and Jia Ke and Haiting Li and Chen Wei and Xueqian Wu and Jing Li and Yang Yang and Lu Xu and Hongzhuo Liu and Sanming Li and Mingshi Yang and Minjei Wei",
year = "2018",
doi = "10.1016/j.msec.2018.07.081",
language = "English",
volume = "93",
pages = "407--418",
journal = "Materials Science & Engineering A: Structural Materials: Properties, Microstructure and Processing",
issn = "0921-5093",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Mesoporous silicas templated by heterocyclic amino acid derivatives

T2 - Biomimetic synthesis and drug release application

AU - Li, Heran

AU - Ke, Jia

AU - Li, Haiting

AU - Wei, Chen

AU - Wu, Xueqian

AU - Li, Jing

AU - Yang, Yang

AU - Xu, Lu

AU - Liu, Hongzhuo

AU - Li, Sanming

AU - Yang, Mingshi

AU - Wei, Minjei

PY - 2018

Y1 - 2018

N2 - The present paper reported a biomimetic synthesis of mesoporous silicas (BMSs) at room temperature by using synthesized polymers (C 16 -L-His, C 16 -L-Pro and C 16 -L-Trp) which derived from amino acid with ring structures as template under basic condition via co-structural-directing-agent method. The formation mechanism of BMSs and effect of initial synthesis conditions (such as surfactant structure, pH and co-solvents) on morphology and structure of BMSs were systematically studied. Synthesized BMSs were characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and nitrogen adsorption/desorption isotherms. The results showed that the surfactant structure was the dominant factor to direct the final mesostructure of BMSs, since the structure of surfactant affected the structure and size of clusters. Meanwhile the generation of BMSs required very rigorous alkaline condition which controlled the ionization degree of the surfactant and thus contributing to adequate stacking energy. Higher pH resulted in construction of channels with higher curvature. The presence of ethanol was found to facilitate the formation of BMSs with larger particle size. In application, aspirin can be loaded into BMSs with high efficiency, and the drug crystalline state of aspirin transformed from crystalline state to amorphous state during this process, which undoubtedly lead to the improvement of drug dissolution from 72.8% to 100% within 90 min. It is convincible that the biomimetic method presented here provided novel insight on precisely control of mesoporous silica and undoubtedly promoted the application of mesoporous silica materials.

AB - The present paper reported a biomimetic synthesis of mesoporous silicas (BMSs) at room temperature by using synthesized polymers (C 16 -L-His, C 16 -L-Pro and C 16 -L-Trp) which derived from amino acid with ring structures as template under basic condition via co-structural-directing-agent method. The formation mechanism of BMSs and effect of initial synthesis conditions (such as surfactant structure, pH and co-solvents) on morphology and structure of BMSs were systematically studied. Synthesized BMSs were characterized by transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and nitrogen adsorption/desorption isotherms. The results showed that the surfactant structure was the dominant factor to direct the final mesostructure of BMSs, since the structure of surfactant affected the structure and size of clusters. Meanwhile the generation of BMSs required very rigorous alkaline condition which controlled the ionization degree of the surfactant and thus contributing to adequate stacking energy. Higher pH resulted in construction of channels with higher curvature. The presence of ethanol was found to facilitate the formation of BMSs with larger particle size. In application, aspirin can be loaded into BMSs with high efficiency, and the drug crystalline state of aspirin transformed from crystalline state to amorphous state during this process, which undoubtedly lead to the improvement of drug dissolution from 72.8% to 100% within 90 min. It is convincible that the biomimetic method presented here provided novel insight on precisely control of mesoporous silica and undoubtedly promoted the application of mesoporous silica materials.

KW - Biomimetic synthesis nanomaterial

KW - Drug delivery

KW - Dynamic self-assembly

KW - Mesoporous silica

U2 - 10.1016/j.msec.2018.07.081

DO - 10.1016/j.msec.2018.07.081

M3 - Journal article

C2 - 30274073

AN - SCOPUS:85051102895

VL - 93

SP - 407

EP - 418

JO - Materials Science & Engineering A: Structural Materials: Properties, Microstructure and Processing

JF - Materials Science & Engineering A: Structural Materials: Properties, Microstructure and Processing

SN - 0921-5093

ER -

ID: 220856275