Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy. / Kao, J. Y.; McGoverin, C. M.; Graeser, K. A.; Rades, T.; Gordon, K. C.

In: Vibrational Spectroscopy, Vol. 58, 01.2012, p. 19-26.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kao, JY, McGoverin, CM, Graeser, KA, Rades, T & Gordon, KC 2012, 'Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy', Vibrational Spectroscopy, vol. 58, pp. 19-26. https://doi.org/10.1016/j.vibspec.2011.09.009

APA

Kao, J. Y., McGoverin, C. M., Graeser, K. A., Rades, T., & Gordon, K. C. (2012). Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy. Vibrational Spectroscopy, 58, 19-26. https://doi.org/10.1016/j.vibspec.2011.09.009

Vancouver

Kao JY, McGoverin CM, Graeser KA, Rades T, Gordon KC. Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy. Vibrational Spectroscopy. 2012 Jan;58:19-26. https://doi.org/10.1016/j.vibspec.2011.09.009

Author

Kao, J. Y. ; McGoverin, C. M. ; Graeser, K. A. ; Rades, T. ; Gordon, K. C. / Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy. In: Vibrational Spectroscopy. 2012 ; Vol. 58. pp. 19-26.

Bibtex

@article{421dbca76495473e8e3a3a4f44a8bdbc,
title = "Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy",
abstract = "The recrystallisation of amorphous indomethacin (IMC) has been investigated using NIR and Raman spectroscopy and differential scanning calorimetry (DSC). Two methods were used to prepare the amorphous state (ball-milling, and melting and quench-cooling) and samples were stored under three sets of conditions (25 °C dry, 40 °C dry and 40 °C at 75% RH). The recrystallisation of amorphous IMC was quantified by DSC and compared to trends observed using Raman and NIR data. It was found that the multivariate analysis of Raman data agreed better with DSC data than univariate NIR or Raman analyses, or multivariate NIR analyses. The quenched-cooled samples were spiked with crystalline seeds (0 and 5%) and the rates of recrystallisation compared with ball-milled samples. It was found that the ball-milled samples rapidly recrystallised (within 20 days) but quench-cooled samples retained amorphous content for 20 days, even when spiked with γ-IMC to 5% (w/w) level.",
keywords = "Amorphous stability, Indomethacin, Near infrared, Principal component analysis, Raman",
author = "Kao, {J. Y.} and McGoverin, {C. M.} and Graeser, {K. A.} and T. Rades and Gordon, {K. C.}",
year = "2012",
month = jan,
doi = "10.1016/j.vibspec.2011.09.009",
language = "English",
volume = "58",
pages = "19--26",
journal = "Vibrational Spectroscopy",
issn = "0924-2031",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy

AU - Kao, J. Y.

AU - McGoverin, C. M.

AU - Graeser, K. A.

AU - Rades, T.

AU - Gordon, K. C.

PY - 2012/1

Y1 - 2012/1

N2 - The recrystallisation of amorphous indomethacin (IMC) has been investigated using NIR and Raman spectroscopy and differential scanning calorimetry (DSC). Two methods were used to prepare the amorphous state (ball-milling, and melting and quench-cooling) and samples were stored under three sets of conditions (25 °C dry, 40 °C dry and 40 °C at 75% RH). The recrystallisation of amorphous IMC was quantified by DSC and compared to trends observed using Raman and NIR data. It was found that the multivariate analysis of Raman data agreed better with DSC data than univariate NIR or Raman analyses, or multivariate NIR analyses. The quenched-cooled samples were spiked with crystalline seeds (0 and 5%) and the rates of recrystallisation compared with ball-milled samples. It was found that the ball-milled samples rapidly recrystallised (within 20 days) but quench-cooled samples retained amorphous content for 20 days, even when spiked with γ-IMC to 5% (w/w) level.

AB - The recrystallisation of amorphous indomethacin (IMC) has been investigated using NIR and Raman spectroscopy and differential scanning calorimetry (DSC). Two methods were used to prepare the amorphous state (ball-milling, and melting and quench-cooling) and samples were stored under three sets of conditions (25 °C dry, 40 °C dry and 40 °C at 75% RH). The recrystallisation of amorphous IMC was quantified by DSC and compared to trends observed using Raman and NIR data. It was found that the multivariate analysis of Raman data agreed better with DSC data than univariate NIR or Raman analyses, or multivariate NIR analyses. The quenched-cooled samples were spiked with crystalline seeds (0 and 5%) and the rates of recrystallisation compared with ball-milled samples. It was found that the ball-milled samples rapidly recrystallised (within 20 days) but quench-cooled samples retained amorphous content for 20 days, even when spiked with γ-IMC to 5% (w/w) level.

KW - Amorphous stability

KW - Indomethacin

KW - Near infrared

KW - Principal component analysis

KW - Raman

UR - http://www.scopus.com/inward/record.url?scp=84855798755&partnerID=8YFLogxK

U2 - 10.1016/j.vibspec.2011.09.009

DO - 10.1016/j.vibspec.2011.09.009

M3 - Journal article

AN - SCOPUS:84855798755

VL - 58

SP - 19

EP - 26

JO - Vibrational Spectroscopy

JF - Vibrational Spectroscopy

SN - 0924-2031

ER -

ID: 299415987