Lab-on-a-chip technologies for stem cell analysis
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Lab-on-a-chip technologies for stem cell analysis. / Ertl, Peter; Sticker, Drago; Charwat, Verena; Kasper, Cornelia; Lepperdinger, Günter.
In: Trends in Biotechnology, Vol. 32, No. 5, 05.2014, p. 245-53.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Lab-on-a-chip technologies for stem cell analysis
AU - Ertl, Peter
AU - Sticker, Drago
AU - Charwat, Verena
AU - Kasper, Cornelia
AU - Lepperdinger, Günter
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014/5
Y1 - 2014/5
N2 - The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of analyzing cell cultures under physiologically relevant conditions. In the present review, we address recent lab-on-a-chip developments for stem cell analysis. We highlight in particular the tangible advantages of microfluidic devices to overcome most of the challenges associated with stem cell identification, expansion and differentiation, with the greatest advantage being that lab-on-a-chip technology allows for the precise regulation of culturing conditions, while simultaneously monitoring relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of stem cell cultures are presented and their potential future applications discussed.
AB - The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of analyzing cell cultures under physiologically relevant conditions. In the present review, we address recent lab-on-a-chip developments for stem cell analysis. We highlight in particular the tangible advantages of microfluidic devices to overcome most of the challenges associated with stem cell identification, expansion and differentiation, with the greatest advantage being that lab-on-a-chip technology allows for the precise regulation of culturing conditions, while simultaneously monitoring relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of stem cell cultures are presented and their potential future applications discussed.
KW - Cytological Techniques
KW - Humans
KW - Lab-On-A-Chip Devices
KW - Microfluidic Analytical Techniques
KW - Stem Cells
KW - Journal Article
KW - Review
U2 - 10.1016/j.tibtech.2014.03.004
DO - 10.1016/j.tibtech.2014.03.004
M3 - Review
C2 - 24726257
VL - 32
SP - 245
EP - 253
JO - Trends in Biotechnology
JF - Trends in Biotechnology
SN - 0167-7799
IS - 5
ER -
ID: 183799690