Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax

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Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax. / Rwegoshora, Frank; Mabiki, Faith; Machumi, Francis; Chacha, Musa; Styrishave, Bjarne; Cornett, Claus.

In: The Journal of Phytopharmacology, Vol. 11, No. 5, 2022, p. 347-352.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rwegoshora, F, Mabiki, F, Machumi, F, Chacha, M, Styrishave, B & Cornett, C 2022, 'Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax', The Journal of Phytopharmacology, vol. 11, no. 5, pp. 347-352. https://doi.org/10.31254/phyto.2022.11506

APA

Rwegoshora, F., Mabiki, F., Machumi, F., Chacha, M., Styrishave, B., & Cornett, C. (2022). Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax. The Journal of Phytopharmacology, 11(5), 347-352. https://doi.org/10.31254/phyto.2022.11506

Vancouver

Rwegoshora F, Mabiki F, Machumi F, Chacha M, Styrishave B, Cornett C. Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax. The Journal of Phytopharmacology. 2022;11(5):347-352. https://doi.org/10.31254/phyto.2022.11506

Author

Rwegoshora, Frank ; Mabiki, Faith ; Machumi, Francis ; Chacha, Musa ; Styrishave, Bjarne ; Cornett, Claus. / Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax. In: The Journal of Phytopharmacology. 2022 ; Vol. 11, No. 5. pp. 347-352.

Bibtex

@article{e589cc7a832e4c40b08c009a4d56d76a,
title = "Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax",
abstract = "The use of plants as sources of drug agents is attributed by factors among which are the easyaccessibility to plants, less toxicity and little or no drug resistance. An improvement in both traditionalmedicine and drug discovery field necessitates investigation of pure compounds in any plant withmedicinal value. Synadenium glaucescens Pax of the family Euphorbiaceae is among the medicinal plantin Tanzania which are proven to contain bioactive compounds against microbial infections. Analysis ofethanolic and methanolic extracts of root and stem barks respectively aided to isolated six purecompounds (SG1- 6). These compounds were analyzed by both 1D, 2D NMR and GC-MS while theirspectral processing was achieved in the Bruker TopSpin 3.6.2. Among these compounds, one was aphenolic (hemicosanyl ferulate-SG1), three triterpenoids, (lupeol- SG2, epifriedelanol- SG4 and eupholSG5), one steroid (?-sitosterol- SG6) and a long chain alkene (1-nonacosene- SG2). Cytotoxicityevaluation by Brine shrimp lethality test (BLST) indicated the compounds under report were practicallynon-toxic.",
author = "Frank Rwegoshora and Faith Mabiki and Francis Machumi and Musa Chacha and Bjarne Styrishave and Claus Cornett",
year = "2022",
doi = "10.31254/phyto.2022.11506",
language = "English",
volume = "11",
pages = "347--352",
journal = "The Journal of Phytopharmacology",
number = "5",

}

RIS

TY - JOUR

T1 - Isolation and toxicity evaluation of feruloyl ester and other triterpenoids from Synadenium glaucescens Pax

AU - Rwegoshora, Frank

AU - Mabiki, Faith

AU - Machumi, Francis

AU - Chacha, Musa

AU - Styrishave, Bjarne

AU - Cornett, Claus

PY - 2022

Y1 - 2022

N2 - The use of plants as sources of drug agents is attributed by factors among which are the easyaccessibility to plants, less toxicity and little or no drug resistance. An improvement in both traditionalmedicine and drug discovery field necessitates investigation of pure compounds in any plant withmedicinal value. Synadenium glaucescens Pax of the family Euphorbiaceae is among the medicinal plantin Tanzania which are proven to contain bioactive compounds against microbial infections. Analysis ofethanolic and methanolic extracts of root and stem barks respectively aided to isolated six purecompounds (SG1- 6). These compounds were analyzed by both 1D, 2D NMR and GC-MS while theirspectral processing was achieved in the Bruker TopSpin 3.6.2. Among these compounds, one was aphenolic (hemicosanyl ferulate-SG1), three triterpenoids, (lupeol- SG2, epifriedelanol- SG4 and eupholSG5), one steroid (?-sitosterol- SG6) and a long chain alkene (1-nonacosene- SG2). Cytotoxicityevaluation by Brine shrimp lethality test (BLST) indicated the compounds under report were practicallynon-toxic.

AB - The use of plants as sources of drug agents is attributed by factors among which are the easyaccessibility to plants, less toxicity and little or no drug resistance. An improvement in both traditionalmedicine and drug discovery field necessitates investigation of pure compounds in any plant withmedicinal value. Synadenium glaucescens Pax of the family Euphorbiaceae is among the medicinal plantin Tanzania which are proven to contain bioactive compounds against microbial infections. Analysis ofethanolic and methanolic extracts of root and stem barks respectively aided to isolated six purecompounds (SG1- 6). These compounds were analyzed by both 1D, 2D NMR and GC-MS while theirspectral processing was achieved in the Bruker TopSpin 3.6.2. Among these compounds, one was aphenolic (hemicosanyl ferulate-SG1), three triterpenoids, (lupeol- SG2, epifriedelanol- SG4 and eupholSG5), one steroid (?-sitosterol- SG6) and a long chain alkene (1-nonacosene- SG2). Cytotoxicityevaluation by Brine shrimp lethality test (BLST) indicated the compounds under report were practicallynon-toxic.

U2 - 10.31254/phyto.2022.11506

DO - 10.31254/phyto.2022.11506

M3 - Journal article

VL - 11

SP - 347

EP - 352

JO - The Journal of Phytopharmacology

JF - The Journal of Phytopharmacology

IS - 5

ER -

ID: 361321968