Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation

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Insight into Nanoscale Network of Spray-dried Polymeric Particles : Role of Polymer Molecular Conformation. / Wan, Feng; Larsen, Flemming Hofmann; Nunes Bordallo, Heloisa; Foged, Camilla; Rantanen, Jukka; Yang, Mingshi.

In: A C S Applied Materials and Interfaces, Vol. 10, No. 43, 2018, p. 36686-36692.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wan, F, Larsen, FH, Nunes Bordallo, H, Foged, C, Rantanen, J & Yang, M 2018, 'Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation', A C S Applied Materials and Interfaces, vol. 10, no. 43, pp. 36686-36692. https://doi.org/10.1021/acsami.8b12475

APA

Wan, F., Larsen, F. H., Nunes Bordallo, H., Foged, C., Rantanen, J., & Yang, M. (2018). Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation. A C S Applied Materials and Interfaces, 10(43), 36686-36692. https://doi.org/10.1021/acsami.8b12475

Vancouver

Wan F, Larsen FH, Nunes Bordallo H, Foged C, Rantanen J, Yang M. Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation. A C S Applied Materials and Interfaces. 2018;10(43):36686-36692. https://doi.org/10.1021/acsami.8b12475

Author

Wan, Feng ; Larsen, Flemming Hofmann ; Nunes Bordallo, Heloisa ; Foged, Camilla ; Rantanen, Jukka ; Yang, Mingshi. / Insight into Nanoscale Network of Spray-dried Polymeric Particles : Role of Polymer Molecular Conformation. In: A C S Applied Materials and Interfaces. 2018 ; Vol. 10, No. 43. pp. 36686-36692.

Bibtex

@article{c561ee5d5ed441e7a2836ea109928a6e,
title = "Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation",
abstract = "Poly (DL-lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal that the role of PLGA molecular conformation in particle formation and drug release. The nanoscale mobility of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using nuclear magnetic resonance (NMR) and neutron scattering. By employing chemometric method, we further demonstrated the evolution of nanoscale networks in spray-dried PLGA microparticles upon the water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in that the more resistant network against the water absorption in the spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving the customized drug release from PLGA microparticles.",
author = "Feng Wan and Larsen, {Flemming Hofmann} and {Nunes Bordallo}, Heloisa and Camilla Foged and Jukka Rantanen and Mingshi Yang",
year = "2018",
doi = "10.1021/acsami.8b12475",
language = "English",
volume = "10",
pages = "36686--36692",
journal = "A C S Applied Materials and Interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "43",

}

RIS

TY - JOUR

T1 - Insight into Nanoscale Network of Spray-dried Polymeric Particles

T2 - Role of Polymer Molecular Conformation

AU - Wan, Feng

AU - Larsen, Flemming Hofmann

AU - Nunes Bordallo, Heloisa

AU - Foged, Camilla

AU - Rantanen, Jukka

AU - Yang, Mingshi

PY - 2018

Y1 - 2018

N2 - Poly (DL-lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal that the role of PLGA molecular conformation in particle formation and drug release. The nanoscale mobility of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using nuclear magnetic resonance (NMR) and neutron scattering. By employing chemometric method, we further demonstrated the evolution of nanoscale networks in spray-dried PLGA microparticles upon the water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in that the more resistant network against the water absorption in the spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving the customized drug release from PLGA microparticles.

AB - Poly (DL-lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal that the role of PLGA molecular conformation in particle formation and drug release. The nanoscale mobility of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using nuclear magnetic resonance (NMR) and neutron scattering. By employing chemometric method, we further demonstrated the evolution of nanoscale networks in spray-dried PLGA microparticles upon the water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in that the more resistant network against the water absorption in the spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving the customized drug release from PLGA microparticles.

U2 - 10.1021/acsami.8b12475

DO - 10.1021/acsami.8b12475

M3 - Journal article

VL - 10

SP - 36686

EP - 36692

JO - A C S Applied Materials and Interfaces

JF - A C S Applied Materials and Interfaces

SN - 1944-8244

IS - 43

ER -

ID: 203167409