Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats

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Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats. / Karpf, Ditte M; Holm, René; Kristensen, Henning G; Müllertz, Anette.

In: Pharmaceutical Research, Vol. 21, No. 8, 2004, p. 1413-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Karpf, DM, Holm, R, Kristensen, HG & Müllertz, A 2004, 'Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats', Pharmaceutical Research, vol. 21, no. 8, pp. 1413-8.

APA

Karpf, D. M., Holm, R., Kristensen, H. G., & Müllertz, A. (2004). Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats. Pharmaceutical Research, 21(8), 1413-8.

Vancouver

Karpf DM, Holm R, Kristensen HG, Müllertz A. Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats. Pharmaceutical Research. 2004;21(8):1413-8.

Author

Karpf, Ditte M ; Holm, René ; Kristensen, Henning G ; Müllertz, Anette. / Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats. In: Pharmaceutical Research. 2004 ; Vol. 21, No. 8. pp. 1413-8.

Bibtex

@article{0bdefde0c5ec11dd9473000ea68e967b,
title = "Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats",
abstract = "PURPOSE: To compare the lymphatic transport and the portal absorption of halofantrine (Hf) when administered in (i) a triacylglycerol (TG) solution, (ii) an o/w-emulsion that contains a metabolizable surfactant, and (iii) an o/w-emulsion that contains a synthetic surfactant. METHODS: Lymph cannulated rats were orally dosed with Hf in a TG solution or in o/w-emulsions dispersed by lecithin or Cremophor RH40. Lymph was continuously collected, and blood was sampled periodically in the course of 30 h. Hf in the lymph and blood and TG and phosphatidyl choline (PC) in the lymph were analyzed. RESULTS: A significantly (p < 0.05) higher level of Hf was found in the intestinal lymph when dosed in one of the emulsions (22.8+/-2.8{\%} and 20.2+/-2.5{\%}) compared to in the TG solution (7.9+/-1.1{\%}). No difference in the lymphatic transport of Hf was observed between the two emulsions. The portal absorption of Hf was similar for the three vehicles. CONCLUSIONS: The emulsified vehicles favor an increased lymphatic transport of Hf. The portal transport of Hf was not significantly different for the three vehicles. This indicates that a different degree of dispersion of the TG vehicle can change the route of transportation of Hf.",
author = "Karpf, {Ditte M} and Ren{\'e} Holm and Kristensen, {Henning G} and Anette M{\"u}llertz",
note = "Keywords: Administration, Oral; Animals; Biological Availability; Biological Transport; Drug Delivery Systems; Emulsions; Injections, Intravenous; Intestines; Lymph; Lymphatic System; Male; Phenanthrenes; Phosphatidylcholines; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Surface-Active Agents; Triglycerides",
year = "2004",
language = "English",
volume = "21",
pages = "1413--8",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats

AU - Karpf, Ditte M

AU - Holm, René

AU - Kristensen, Henning G

AU - Müllertz, Anette

N1 - Keywords: Administration, Oral; Animals; Biological Availability; Biological Transport; Drug Delivery Systems; Emulsions; Injections, Intravenous; Intestines; Lymph; Lymphatic System; Male; Phenanthrenes; Phosphatidylcholines; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Surface-Active Agents; Triglycerides

PY - 2004

Y1 - 2004

N2 - PURPOSE: To compare the lymphatic transport and the portal absorption of halofantrine (Hf) when administered in (i) a triacylglycerol (TG) solution, (ii) an o/w-emulsion that contains a metabolizable surfactant, and (iii) an o/w-emulsion that contains a synthetic surfactant. METHODS: Lymph cannulated rats were orally dosed with Hf in a TG solution or in o/w-emulsions dispersed by lecithin or Cremophor RH40. Lymph was continuously collected, and blood was sampled periodically in the course of 30 h. Hf in the lymph and blood and TG and phosphatidyl choline (PC) in the lymph were analyzed. RESULTS: A significantly (p < 0.05) higher level of Hf was found in the intestinal lymph when dosed in one of the emulsions (22.8+/-2.8% and 20.2+/-2.5%) compared to in the TG solution (7.9+/-1.1%). No difference in the lymphatic transport of Hf was observed between the two emulsions. The portal absorption of Hf was similar for the three vehicles. CONCLUSIONS: The emulsified vehicles favor an increased lymphatic transport of Hf. The portal transport of Hf was not significantly different for the three vehicles. This indicates that a different degree of dispersion of the TG vehicle can change the route of transportation of Hf.

AB - PURPOSE: To compare the lymphatic transport and the portal absorption of halofantrine (Hf) when administered in (i) a triacylglycerol (TG) solution, (ii) an o/w-emulsion that contains a metabolizable surfactant, and (iii) an o/w-emulsion that contains a synthetic surfactant. METHODS: Lymph cannulated rats were orally dosed with Hf in a TG solution or in o/w-emulsions dispersed by lecithin or Cremophor RH40. Lymph was continuously collected, and blood was sampled periodically in the course of 30 h. Hf in the lymph and blood and TG and phosphatidyl choline (PC) in the lymph were analyzed. RESULTS: A significantly (p < 0.05) higher level of Hf was found in the intestinal lymph when dosed in one of the emulsions (22.8+/-2.8% and 20.2+/-2.5%) compared to in the TG solution (7.9+/-1.1%). No difference in the lymphatic transport of Hf was observed between the two emulsions. The portal absorption of Hf was similar for the three vehicles. CONCLUSIONS: The emulsified vehicles favor an increased lymphatic transport of Hf. The portal transport of Hf was not significantly different for the three vehicles. This indicates that a different degree of dispersion of the TG vehicle can change the route of transportation of Hf.

M3 - Journal article

C2 - 15359576

VL - 21

SP - 1413

EP - 1418

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 8

ER -

ID: 9013054