Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. / Zhang, Fang; Aaltonen, Jaakko; Tian, Fang; Saville, Dorothy J; Rades, Thomas.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 71, No. 1, 2009, p. 64-70.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhang, F, Aaltonen, J, Tian, F, Saville, DJ & Rades, T 2009, 'Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin', European Journal of Pharmaceutics and Biopharmaceutics, vol. 71, no. 1, pp. 64-70. https://doi.org/10.1016/j.ejpb.2008.07.010

APA

Zhang, F., Aaltonen, J., Tian, F., Saville, D. J., & Rades, T. (2009). Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. European Journal of Pharmaceutics and Biopharmaceutics, 71(1), 64-70. https://doi.org/10.1016/j.ejpb.2008.07.010

Vancouver

Zhang F, Aaltonen J, Tian F, Saville DJ, Rades T. Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. European Journal of Pharmaceutics and Biopharmaceutics. 2009;71(1):64-70. https://doi.org/10.1016/j.ejpb.2008.07.010

Author

Zhang, Fang ; Aaltonen, Jaakko ; Tian, Fang ; Saville, Dorothy J ; Rades, Thomas. / Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin. In: European Journal of Pharmaceutics and Biopharmaceutics. 2009 ; Vol. 71, No. 1. pp. 64-70.

Bibtex

@article{0bf6b090864711de8bc9000ea68e967b,
title = "Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin",
abstract = "This study investigated the factors influencing the stability of amorphous simvastatin. Quench-cooled amorphous simvastatin in two particle size ranges, 150-180 microm (QC-big) and CM>crystalline. For the physical stability, the highest crystallization rate was observed for CM, and the slowest rate was detected for QC-big, with an intermediate rate occurring for QC-small. QC exhibited lower molecular mobility and higher chemical degradation than CM. Therefore, the current study demonstrated that QC and CM have obvious differences in both physical and chemical properties. It was concluded that care should be taken when choosing preparation methods for making amorphous materials. Furthermore, particle size, a factor that has often been overlooked when dealing with amorphous materials, was shown to have an influence on physical stability of amorphous simvastatin.",
keywords = "Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Chromatography, High Pressure Liquid, Crystallization, Drug Stability, Particle Size, Simvastatin, Solubility, Spectroscopy, Fourier Transform Infrared, Technology, Pharmaceutical, Thermodynamics, X-Ray Diffraction",
author = "Fang Zhang and Jaakko Aaltonen and Fang Tian and Saville, {Dorothy J} and Thomas Rades",
year = "2009",
doi = "10.1016/j.ejpb.2008.07.010",
language = "English",
volume = "71",
pages = "64--70",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Influence of particle size and preparation methods on the physical and chemical stability of amorphous simvastatin

AU - Zhang, Fang

AU - Aaltonen, Jaakko

AU - Tian, Fang

AU - Saville, Dorothy J

AU - Rades, Thomas

PY - 2009

Y1 - 2009

N2 - This study investigated the factors influencing the stability of amorphous simvastatin. Quench-cooled amorphous simvastatin in two particle size ranges, 150-180 microm (QC-big) and CM>crystalline. For the physical stability, the highest crystallization rate was observed for CM, and the slowest rate was detected for QC-big, with an intermediate rate occurring for QC-small. QC exhibited lower molecular mobility and higher chemical degradation than CM. Therefore, the current study demonstrated that QC and CM have obvious differences in both physical and chemical properties. It was concluded that care should be taken when choosing preparation methods for making amorphous materials. Furthermore, particle size, a factor that has often been overlooked when dealing with amorphous materials, was shown to have an influence on physical stability of amorphous simvastatin.

AB - This study investigated the factors influencing the stability of amorphous simvastatin. Quench-cooled amorphous simvastatin in two particle size ranges, 150-180 microm (QC-big) and CM>crystalline. For the physical stability, the highest crystallization rate was observed for CM, and the slowest rate was detected for QC-big, with an intermediate rate occurring for QC-small. QC exhibited lower molecular mobility and higher chemical degradation than CM. Therefore, the current study demonstrated that QC and CM have obvious differences in both physical and chemical properties. It was concluded that care should be taken when choosing preparation methods for making amorphous materials. Furthermore, particle size, a factor that has often been overlooked when dealing with amorphous materials, was shown to have an influence on physical stability of amorphous simvastatin.

KW - Calorimetry, Differential Scanning

KW - Chemistry, Pharmaceutical

KW - Chromatography, High Pressure Liquid

KW - Crystallization

KW - Drug Stability

KW - Particle Size

KW - Simvastatin

KW - Solubility

KW - Spectroscopy, Fourier Transform Infrared

KW - Technology, Pharmaceutical

KW - Thermodynamics

KW - X-Ray Diffraction

U2 - 10.1016/j.ejpb.2008.07.010

DO - 10.1016/j.ejpb.2008.07.010

M3 - Journal article

C2 - 18703139

VL - 71

SP - 64

EP - 70

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

IS - 1

ER -

ID: 13674386