In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B. / Kontogiannidou, Eleni; Meikopoulos, Thomas; Gika, Helen; Panteris, Emmanuel; Vizirianakis, Ioannis S; Müllertz, Anette; Fatouros, Dimitrios G.

In: Pharmaceutics, Vol. 12, No. 8, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kontogiannidou, E, Meikopoulos, T, Gika, H, Panteris, E, Vizirianakis, IS, Müllertz, A & Fatouros, DG 2020, 'In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B', Pharmaceutics, vol. 12, no. 8. https://doi.org/10.3390/pharmaceutics12080699

APA

Kontogiannidou, E., Meikopoulos, T., Gika, H., Panteris, E., Vizirianakis, I. S., Müllertz, A., & Fatouros, D. G. (2020). In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B. Pharmaceutics, 12(8). https://doi.org/10.3390/pharmaceutics12080699

Vancouver

Kontogiannidou E, Meikopoulos T, Gika H, Panteris E, Vizirianakis IS, Müllertz A et al. In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B. Pharmaceutics. 2020;12(8). https://doi.org/10.3390/pharmaceutics12080699

Author

Kontogiannidou, Eleni ; Meikopoulos, Thomas ; Gika, Helen ; Panteris, Emmanuel ; Vizirianakis, Ioannis S ; Müllertz, Anette ; Fatouros, Dimitrios G. / In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B. In: Pharmaceutics. 2020 ; Vol. 12, No. 8.

Bibtex

@article{6ab654ffeead4ab7b874efa3326a2dc0,
title = "In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B",
abstract = "Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.",
author = "Eleni Kontogiannidou and Thomas Meikopoulos and Helen Gika and Emmanuel Panteris and Vizirianakis, {Ioannis S} and Anette M{\"u}llertz and Fatouros, {Dimitrios G}",
year = "2020",
doi = "10.3390/pharmaceutics12080699",
language = "English",
volume = "12",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

AU - Kontogiannidou, Eleni

AU - Meikopoulos, Thomas

AU - Gika, Helen

AU - Panteris, Emmanuel

AU - Vizirianakis, Ioannis S

AU - Müllertz, Anette

AU - Fatouros, Dimitrios G

PY - 2020

Y1 - 2020

N2 - Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.

AB - Amphotericin B (AmpB), one of the most commonly used agents in the treatment of severe fungal infections and life-threatening parasitic diseases such as visceral Leishmaniasis, has a negligible oral bioavailability, primarily due to a low solubility and permeability. To develop an oral formulation, medium chain triglycerides and nonionic surfactants in a self-nano-emulsifying drug delivery system (SNEDDS) containing AmpB were combined with room temperature ionic liquids (RTILs) of imidazolium. The presence of ionic liquids significantly enhanced the solubility of AmpB, exhibited a low toxicity and increased the transport of AmpB across Caco-2 cell monolayers. The combination of RTILs with a lipid formulation might be a promising strategy to improve the oral bioavailability of AmpB.

U2 - 10.3390/pharmaceutics12080699

DO - 10.3390/pharmaceutics12080699

M3 - Journal article

C2 - 32722400

VL - 12

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 8

ER -

ID: 247818255