In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends
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In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends. / Berthelsen, Ragna; Klitgaard, Mette; Rades, Thomas; Müllertz, Anette.
In: Advanced Drug Delivery Reviews, Vol. 142, 29.06.2019, p. 35-49.Research output: Contribution to journal › Review › peer-review
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TY - JOUR
T1 - In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends
AU - Berthelsen, Ragna
AU - Klitgaard, Mette
AU - Rades, Thomas
AU - Müllertz, Anette
N1 - Copyright © 2019 Elsevier B.V. All rights reserved.
PY - 2019/6/29
Y1 - 2019/6/29
N2 - During the past two decades, a range of in vitro models simulating the digestion processes occurring in the stomach and small intestine have been developed to characterize lipid based drug delivery systems (LbDDSs). This review describes the presently existing range of in vitro digestion models and their use in the field of oral drug delivery. The models are evaluated in terms of their suitability to assess LbDDSs, and their ability to produce in vitro - in vivo correlations (IVIVCs). While the pH-stat lipolysis model is by far the most commonly utilized in vitro digestion model in relation to characterizing LbDDSs, a series of recent studies have shown a lack of IVIVCs limiting its future use. Presently, no single in vitro digestion model exists which is able to predict the in vivo performance of various LbDDSs. However, recent research has shown the potential of combined digestion-permeation models as well as species specific digestion models.
AB - During the past two decades, a range of in vitro models simulating the digestion processes occurring in the stomach and small intestine have been developed to characterize lipid based drug delivery systems (LbDDSs). This review describes the presently existing range of in vitro digestion models and their use in the field of oral drug delivery. The models are evaluated in terms of their suitability to assess LbDDSs, and their ability to produce in vitro - in vivo correlations (IVIVCs). While the pH-stat lipolysis model is by far the most commonly utilized in vitro digestion model in relation to characterizing LbDDSs, a series of recent studies have shown a lack of IVIVCs limiting its future use. Presently, no single in vitro digestion model exists which is able to predict the in vivo performance of various LbDDSs. However, recent research has shown the potential of combined digestion-permeation models as well as species specific digestion models.
U2 - 10.1016/j.addr.2019.06.010
DO - 10.1016/j.addr.2019.06.010
M3 - Review
C2 - 31265861
VL - 142
SP - 35
EP - 49
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -
ID: 229734540