In situ measurement of solvent-mediated phase transformations during dissolution testing

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In situ measurement of solvent-mediated phase transformations during dissolution testing. / Aaltonen, Jaakko; Heinänen, Paula; Peltonen, Leena; Kortejärvi, Hanna; Tanninen, Veli Pekka; Christiansen, Leena; Hirvonen, Jouni; Yliruusi, Jouko; Rantanen, Jukka.

In: Journal of Pharmaceutical Sciences, Vol. 95, No. 12, 12.2006, p. 2730-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Aaltonen, J, Heinänen, P, Peltonen, L, Kortejärvi, H, Tanninen, VP, Christiansen, L, Hirvonen, J, Yliruusi, J & Rantanen, J 2006, 'In situ measurement of solvent-mediated phase transformations during dissolution testing', Journal of Pharmaceutical Sciences, vol. 95, no. 12, pp. 2730-7. https://doi.org/10.1002/jps.20725

APA

Aaltonen, J., Heinänen, P., Peltonen, L., Kortejärvi, H., Tanninen, V. P., Christiansen, L., ... Rantanen, J. (2006). In situ measurement of solvent-mediated phase transformations during dissolution testing. Journal of Pharmaceutical Sciences, 95(12), 2730-7. https://doi.org/10.1002/jps.20725

Vancouver

Aaltonen J, Heinänen P, Peltonen L, Kortejärvi H, Tanninen VP, Christiansen L et al. In situ measurement of solvent-mediated phase transformations during dissolution testing. Journal of Pharmaceutical Sciences. 2006 Dec;95(12):2730-7. https://doi.org/10.1002/jps.20725

Author

Aaltonen, Jaakko ; Heinänen, Paula ; Peltonen, Leena ; Kortejärvi, Hanna ; Tanninen, Veli Pekka ; Christiansen, Leena ; Hirvonen, Jouni ; Yliruusi, Jouko ; Rantanen, Jukka. / In situ measurement of solvent-mediated phase transformations during dissolution testing. In: Journal of Pharmaceutical Sciences. 2006 ; Vol. 95, No. 12. pp. 2730-7.

Bibtex

@article{24f3e7feef904d4db77dc4596e744d83,
title = "In situ measurement of solvent-mediated phase transformations during dissolution testing",
abstract = "In this study, solvent-mediated phase transformations of theophylline (TP) and nitrofurantoin (NF) were measured in a channel flow intrinsic dissolution test system. The test set-up comprised simultaneous measurement of drug concentration in the dissolution medium (with UV-Vis spectrophotometry) and measurement of the solid-state form of the dissolving solid (in situ with Raman spectroscopy). The solid phase transformations were also investigated off-line with scanning electron microscopy. TP anhydrate underwent a transformation to TP monohydrate, and NF anhydrate (form beta) to NF monohydrate (form II). Transformation of TP anhydrate to TP monohydrate resulted in a clear decrease in the dissolution rate, while the transformation of NF anhydrate (form beta) to NF monohydrate (form II) could not be linked as clearly to changes in the dissolution rate. The transformation of TP was an order of magnitude faster than that of NF. The presence of a water absorbing excipient, microcrystalline cellulose, was found to delay the onset of the transformation of TP anhydrate. Combining the measurement of drug concentration in the dissolution medium with the solid phase measurement offers a deeper understanding of the solvent-mediated phase transformation phenomena during dissolution.",
keywords = "Microscopy, Electron, Scanning, Nitrofurantoin, Solubility, Spectrophotometry, Ultraviolet, Spectrum Analysis, Raman, Theophylline, Water, X-Ray Diffraction",
author = "Jaakko Aaltonen and Paula Hein{\"a}nen and Leena Peltonen and Hanna Kortej{\"a}rvi and Tanninen, {Veli Pekka} and Leena Christiansen and Jouni Hirvonen and Jouko Yliruusi and Jukka Rantanen",
note = "(c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association",
year = "2006",
month = "12",
doi = "10.1002/jps.20725",
language = "English",
volume = "95",
pages = "2730--7",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - In situ measurement of solvent-mediated phase transformations during dissolution testing

AU - Aaltonen, Jaakko

AU - Heinänen, Paula

AU - Peltonen, Leena

AU - Kortejärvi, Hanna

AU - Tanninen, Veli Pekka

AU - Christiansen, Leena

AU - Hirvonen, Jouni

AU - Yliruusi, Jouko

AU - Rantanen, Jukka

N1 - (c) 2006 Wiley-Liss, Inc. and the American Pharmacists Association

PY - 2006/12

Y1 - 2006/12

N2 - In this study, solvent-mediated phase transformations of theophylline (TP) and nitrofurantoin (NF) were measured in a channel flow intrinsic dissolution test system. The test set-up comprised simultaneous measurement of drug concentration in the dissolution medium (with UV-Vis spectrophotometry) and measurement of the solid-state form of the dissolving solid (in situ with Raman spectroscopy). The solid phase transformations were also investigated off-line with scanning electron microscopy. TP anhydrate underwent a transformation to TP monohydrate, and NF anhydrate (form beta) to NF monohydrate (form II). Transformation of TP anhydrate to TP monohydrate resulted in a clear decrease in the dissolution rate, while the transformation of NF anhydrate (form beta) to NF monohydrate (form II) could not be linked as clearly to changes in the dissolution rate. The transformation of TP was an order of magnitude faster than that of NF. The presence of a water absorbing excipient, microcrystalline cellulose, was found to delay the onset of the transformation of TP anhydrate. Combining the measurement of drug concentration in the dissolution medium with the solid phase measurement offers a deeper understanding of the solvent-mediated phase transformation phenomena during dissolution.

AB - In this study, solvent-mediated phase transformations of theophylline (TP) and nitrofurantoin (NF) were measured in a channel flow intrinsic dissolution test system. The test set-up comprised simultaneous measurement of drug concentration in the dissolution medium (with UV-Vis spectrophotometry) and measurement of the solid-state form of the dissolving solid (in situ with Raman spectroscopy). The solid phase transformations were also investigated off-line with scanning electron microscopy. TP anhydrate underwent a transformation to TP monohydrate, and NF anhydrate (form beta) to NF monohydrate (form II). Transformation of TP anhydrate to TP monohydrate resulted in a clear decrease in the dissolution rate, while the transformation of NF anhydrate (form beta) to NF monohydrate (form II) could not be linked as clearly to changes in the dissolution rate. The transformation of TP was an order of magnitude faster than that of NF. The presence of a water absorbing excipient, microcrystalline cellulose, was found to delay the onset of the transformation of TP anhydrate. Combining the measurement of drug concentration in the dissolution medium with the solid phase measurement offers a deeper understanding of the solvent-mediated phase transformation phenomena during dissolution.

KW - Microscopy, Electron, Scanning

KW - Nitrofurantoin

KW - Solubility

KW - Spectrophotometry, Ultraviolet

KW - Spectrum Analysis, Raman

KW - Theophylline

KW - Water

KW - X-Ray Diffraction

U2 - 10.1002/jps.20725

DO - 10.1002/jps.20725

M3 - Journal article

VL - 95

SP - 2730

EP - 2737

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 12

ER -

ID: 140618537