Immune stimulating complexes (ISCOMs) and Quil-A containing particulate formulations as vaccine delivery systems

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Immune stimulating complexes (ISCOMs) belong to the group of particulate vaccine delivery systems. These particles have received considerable attention in the field of vaccine delivery systems, especially for subunit vaccines. ISCOMs have a spherical, open and cage-like structure and a particle size of around 40nm. They contain an adjuvant (Quil A or QS 21) and an antigen incorporated into or associated with their colloidal structure, making ISCOMs particulate antigen delivery systems which allow co-delivery of antigen and adjuvant. In this chapter we initially describe the components, microstructures and preparation methods of ISCOMs followed by their mechanism of immune stimulation and their use as vaccines.

Original languageEnglish
Title of host publicationImmunomic Discovery of Adjuvants and Candidate Subunit Vaccines
Number of pages29
PublisherSpringer New York
Publication date1 Jan 2013
ISBN (Print)9781461450696
ISBN (Electronic)9781461450702
Publication statusPublished - 1 Jan 2013

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