Hyperspectral imaging in quality control of inkjet printed personalised dosage forms.
Research output: Contribution to journal › Journal article › Research › peer-review
The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceutical ingredient (API). A solution containing anhydrous theophylline as the model drug was developed as a printable formulation. Single units solid dosage forms (SDFs) were prepared by jetting the solution onto 1cm×1cm areas on carrier substrate with multiple printing passes. It was found that the number of printing passes was in excellent correlation (R(2)=0.9994) with the amount of the dispensed drug (μgcm(-2)) based on the UV calibration plot. The API dose escalation was approximately 7.5μgcm(-2) for each printing pass concluding that inkjet printing technology can optimally provide solutions to accurate deposition of active substances with a potential for personalized dosing. Principal component analysis (PCA) was carried out in order to visualize the trends in the hyperspectral data. Subsequently, a quantitative partial least squares (PLS) regression model was created. NIR hyperspectral imaging proved (R(2)=0.9767) to be a reliable, rapid and non-destructive method to optimize quality control of these planar printed dosage forms.
Original language | English |
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Journal | International Journal of Pharmaceutics |
Volume | 483 |
Issue number | 1-2 |
Pages (from-to) | 244-9 |
Number of pages | 6 |
ISSN | 0378-5173 |
DOIs | |
Publication status | Published - 10 Apr 2015 |
Externally published | Yes |
- Cellulose carrier substrates, Ethanol (PubChem CID: 702), Glycerol (PubChem CID: 753, Inkjet printing, Multivariate analysis, Near infrared hyperspectral imaging, Personalized medicine, Quality control, Theophylline (PubChem CID: 2153)
Research areas
ID: 145539182