Gas Chromatography (GC)
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Gas Chromatography (GC). / Pedersen-Bjergaard, Stig.
Bioanalysis of Pharmaceuticals: Sample Preparation, Chromatography and Mass Spectrometry. Wiley Online, 2015. p. 173-206.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Gas Chromatography (GC)
AU - Pedersen-Bjergaard, Stig
PY - 2015/5/23
Y1 - 2015/5/23
N2 - In Gas Chromatography (GC), a microliter volume of sample is injected into a heated injection port, where the sample constituents immediately are evaporated. The GC oven can be operated in two different ways during the GC separation: in isothermal mode and in temperature programmed mode. In GC, two different types of columns are used: Capillary columns and packed columns. This chapter discusses that the GC-MS can provide important structural information of an unknown compound because interpretation of electron ionization (EI) mass spectra can provide information about the Molecular mass, Elemental composition, Empirical formula and Functional groups. It also discusses that GC-MS can be used for quantitative analysis. There are a large number of detectors available in GC, but only the standard detectors used in bioanalysis are described in the chapter. The chapter discusses the flame ionization detector (FID), the nitrogen-phosphorus detector (NPD), and the electron capture detector (ECD).
AB - In Gas Chromatography (GC), a microliter volume of sample is injected into a heated injection port, where the sample constituents immediately are evaporated. The GC oven can be operated in two different ways during the GC separation: in isothermal mode and in temperature programmed mode. In GC, two different types of columns are used: Capillary columns and packed columns. This chapter discusses that the GC-MS can provide important structural information of an unknown compound because interpretation of electron ionization (EI) mass spectra can provide information about the Molecular mass, Elemental composition, Empirical formula and Functional groups. It also discusses that GC-MS can be used for quantitative analysis. There are a large number of detectors available in GC, but only the standard detectors used in bioanalysis are described in the chapter. The chapter discusses the flame ionization detector (FID), the nitrogen-phosphorus detector (NPD), and the electron capture detector (ECD).
KW - Capillary columns
KW - Electron capture detector
KW - Electron ionization
KW - Flame ionization detector
KW - Gas chromatography
KW - GC instrumentation
KW - GC-MS
KW - Nitrogen phosphorus detector
KW - Packed columns
KW - Retention
UR - http://www.scopus.com/inward/record.url?scp=85018827231&partnerID=8YFLogxK
U2 - 10.1002/9781118716830.ch8
DO - 10.1002/9781118716830.ch8
M3 - Book chapter
AN - SCOPUS:85018827231
SN - 9781118716816
SP - 173
EP - 206
BT - Bioanalysis of Pharmaceuticals
PB - Wiley Online
ER -
ID: 231649721