Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide. / Svagan, Anna Justina; Müllertz, Anette; Löbmann, Korbinian.
In: The Journal of pharmacy and pharmacology, Vol. 69, No. 11, 11.2017, p. 1477-1484.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide
AU - Svagan, Anna Justina
AU - Müllertz, Anette
AU - Löbmann, Korbinian
N1 - © 2017 Royal Pharmaceutical Society.
PY - 2017/11
Y1 - 2017/11
N2 - OBJECTIVES: This study aimed to prepare a furosemide-loaded sustained release cellulose nanofibre (CNF)-based nanofoams with buoyancy.METHODS: Dry foams consisting of CNF and the model drug furosemide at concentrations of 21% and 50% (w/w) have been prepared by simply foaming a CNF-drug suspension followed by drying. The resulting foams were characterized towards their morphology, solid state properties and dissolution kinetics.KEY FINDINGS: Solid state analysis of the resulting drug-loaded foams revealed that the drug was present as an amorphous sodium furosemide salt and in form of furosemide form I crystals embedded in the CNF foam cell walls. The foams could easily be shaped and were flexible, and during the drug release study, the foam pieces remained intact and were floating on the surface due to their positive buoyancy. Both foams showed a sustained furosemide release compared to a marketed tablet. It was found that the extent of sustained release from both foams was dependent on the drug loading, the dimension of the foam piece, as well as the solid state of the drug.CONCLUSIONS: Furosemide-loaded CNF-based foams with sustained release and buoyancy have been successfully prepared in a simple casting and drying procedure.
AB - OBJECTIVES: This study aimed to prepare a furosemide-loaded sustained release cellulose nanofibre (CNF)-based nanofoams with buoyancy.METHODS: Dry foams consisting of CNF and the model drug furosemide at concentrations of 21% and 50% (w/w) have been prepared by simply foaming a CNF-drug suspension followed by drying. The resulting foams were characterized towards their morphology, solid state properties and dissolution kinetics.KEY FINDINGS: Solid state analysis of the resulting drug-loaded foams revealed that the drug was present as an amorphous sodium furosemide salt and in form of furosemide form I crystals embedded in the CNF foam cell walls. The foams could easily be shaped and were flexible, and during the drug release study, the foam pieces remained intact and were floating on the surface due to their positive buoyancy. Both foams showed a sustained furosemide release compared to a marketed tablet. It was found that the extent of sustained release from both foams was dependent on the drug loading, the dimension of the foam piece, as well as the solid state of the drug.CONCLUSIONS: Furosemide-loaded CNF-based foams with sustained release and buoyancy have been successfully prepared in a simple casting and drying procedure.
KW - Journal Article
U2 - 10.1111/jphp.12793
DO - 10.1111/jphp.12793
M3 - Journal article
C2 - 28809440
VL - 69
SP - 1477
EP - 1484
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 11
ER -
ID: 185404103