Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide. / Svagan, Anna Justina; Müllertz, Anette; Löbmann, Korbinian.

In: The Journal of pharmacy and pharmacology, Vol. 69, No. 11, 11.2017, p. 1477-1484.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Svagan, AJ, Müllertz, A & Löbmann, K 2017, 'Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide', The Journal of pharmacy and pharmacology, vol. 69, no. 11, pp. 1477-1484. https://doi.org/10.1111/jphp.12793

APA

Svagan, A. J., Müllertz, A., & Löbmann, K. (2017). Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide. The Journal of pharmacy and pharmacology, 69(11), 1477-1484. https://doi.org/10.1111/jphp.12793

Vancouver

Svagan AJ, Müllertz A, Löbmann K. Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide. The Journal of pharmacy and pharmacology. 2017 Nov;69(11):1477-1484. https://doi.org/10.1111/jphp.12793

Author

Svagan, Anna Justina ; Müllertz, Anette ; Löbmann, Korbinian. / Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide. In: The Journal of pharmacy and pharmacology. 2017 ; Vol. 69, No. 11. pp. 1477-1484.

Bibtex

@article{55eeac169b794e72a56ed3e091cc622a,
title = "Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide",
abstract = "OBJECTIVES: This study aimed to prepare a furosemide-loaded sustained release cellulose nanofibre (CNF)-based nanofoams with buoyancy.METHODS: Dry foams consisting of CNF and the model drug furosemide at concentrations of 21{\%} and 50{\%} (w/w) have been prepared by simply foaming a CNF-drug suspension followed by drying. The resulting foams were characterized towards their morphology, solid state properties and dissolution kinetics.KEY FINDINGS: Solid state analysis of the resulting drug-loaded foams revealed that the drug was present as an amorphous sodium furosemide salt and in form of furosemide form I crystals embedded in the CNF foam cell walls. The foams could easily be shaped and were flexible, and during the drug release study, the foam pieces remained intact and were floating on the surface due to their positive buoyancy. Both foams showed a sustained furosemide release compared to a marketed tablet. It was found that the extent of sustained release from both foams was dependent on the drug loading, the dimension of the foam piece, as well as the solid state of the drug.CONCLUSIONS: Furosemide-loaded CNF-based foams with sustained release and buoyancy have been successfully prepared in a simple casting and drying procedure.",
keywords = "Journal Article",
author = "Svagan, {Anna Justina} and Anette M{\"u}llertz and Korbinian L{\"o}bmann",
note = "{\circledC} 2017 Royal Pharmaceutical Society.",
year = "2017",
month = "11",
doi = "10.1111/jphp.12793",
language = "English",
volume = "69",
pages = "1477--1484",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "JohnWiley & Sons Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

AU - Svagan, Anna Justina

AU - Müllertz, Anette

AU - Löbmann, Korbinian

N1 - © 2017 Royal Pharmaceutical Society.

PY - 2017/11

Y1 - 2017/11

N2 - OBJECTIVES: This study aimed to prepare a furosemide-loaded sustained release cellulose nanofibre (CNF)-based nanofoams with buoyancy.METHODS: Dry foams consisting of CNF and the model drug furosemide at concentrations of 21% and 50% (w/w) have been prepared by simply foaming a CNF-drug suspension followed by drying. The resulting foams were characterized towards their morphology, solid state properties and dissolution kinetics.KEY FINDINGS: Solid state analysis of the resulting drug-loaded foams revealed that the drug was present as an amorphous sodium furosemide salt and in form of furosemide form I crystals embedded in the CNF foam cell walls. The foams could easily be shaped and were flexible, and during the drug release study, the foam pieces remained intact and were floating on the surface due to their positive buoyancy. Both foams showed a sustained furosemide release compared to a marketed tablet. It was found that the extent of sustained release from both foams was dependent on the drug loading, the dimension of the foam piece, as well as the solid state of the drug.CONCLUSIONS: Furosemide-loaded CNF-based foams with sustained release and buoyancy have been successfully prepared in a simple casting and drying procedure.

AB - OBJECTIVES: This study aimed to prepare a furosemide-loaded sustained release cellulose nanofibre (CNF)-based nanofoams with buoyancy.METHODS: Dry foams consisting of CNF and the model drug furosemide at concentrations of 21% and 50% (w/w) have been prepared by simply foaming a CNF-drug suspension followed by drying. The resulting foams were characterized towards their morphology, solid state properties and dissolution kinetics.KEY FINDINGS: Solid state analysis of the resulting drug-loaded foams revealed that the drug was present as an amorphous sodium furosemide salt and in form of furosemide form I crystals embedded in the CNF foam cell walls. The foams could easily be shaped and were flexible, and during the drug release study, the foam pieces remained intact and were floating on the surface due to their positive buoyancy. Both foams showed a sustained furosemide release compared to a marketed tablet. It was found that the extent of sustained release from both foams was dependent on the drug loading, the dimension of the foam piece, as well as the solid state of the drug.CONCLUSIONS: Furosemide-loaded CNF-based foams with sustained release and buoyancy have been successfully prepared in a simple casting and drying procedure.

KW - Journal Article

U2 - 10.1111/jphp.12793

DO - 10.1111/jphp.12793

M3 - Journal article

C2 - 28809440

VL - 69

SP - 1477

EP - 1484

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 11

ER -

ID: 185404103