Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors. / Kueny-Stotz, Marie; Chassaing, Stefan; Brouillard, Raymond; Nielsen, Mogens Peter Cherly; Goeldner, Maurice.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 18, No. 17, 2008, p. 4864-4867.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kueny-Stotz, M, Chassaing, S, Brouillard, R, Nielsen, MPC & Goeldner, M 2008, 'Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors', Bioorganic & Medicinal Chemistry Letters, vol. 18, no. 17, pp. 4864-4867. https://doi.org/10.1016/j.bmcl.2008.07.107

APA

Kueny-Stotz, M., Chassaing, S., Brouillard, R., Nielsen, M. P. C., & Goeldner, M. (2008). Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors. Bioorganic & Medicinal Chemistry Letters, 18(17), 4864-4867. https://doi.org/10.1016/j.bmcl.2008.07.107

Vancouver

Kueny-Stotz M, Chassaing S, Brouillard R, Nielsen MPC, Goeldner M. Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors. Bioorganic & Medicinal Chemistry Letters. 2008;18(17):4864-4867. https://doi.org/10.1016/j.bmcl.2008.07.107

Author

Kueny-Stotz, Marie ; Chassaing, Stefan ; Brouillard, Raymond ; Nielsen, Mogens Peter Cherly ; Goeldner, Maurice. / Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors. In: Bioorganic & Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 17. pp. 4864-4867.

Bibtex

@article{d3b79fd0f43a11ddbf70000ea68e967b,
title = "Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors",
abstract = "The synthesis of a series of derivatized flavylium cations was undertaken and the affinity to the benzodiazepine binding site of the GABA-A receptor evaluated. The observed high affinity for some derivatives (sub-muM range) was explained by an in vitro transformation of the flavylium cations into the corresponding trans-retrochalcones, components which are proposed to be the active species in this series.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Marie Kueny-Stotz and Stefan Chassaing and Raymond Brouillard and Nielsen, {Mogens Peter Cherly} and Maurice Goeldner",
note = "Keywords: Animals; Benzodiazepines; Binding Sites; Brain; Chalcones; Flavonoids; Fluorides; Ligands; Male; Phosphates; Polycyclic Hydrocarbons, Aromatic; Rats; Rats, Wistar; Receptors, GABA-A; Salts",
year = "2008",
doi = "10.1016/j.bmcl.2008.07.107",
language = "English",
volume = "18",
pages = "4864--4867",
journal = "Bioorganic & Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Pergamon Press",
number = "17",

}

RIS

TY - JOUR

T1 - Flavylium salts as in vitro precursors of potent ligands to brain GABA-A receptors

AU - Kueny-Stotz, Marie

AU - Chassaing, Stefan

AU - Brouillard, Raymond

AU - Nielsen, Mogens Peter Cherly

AU - Goeldner, Maurice

N1 - Keywords: Animals; Benzodiazepines; Binding Sites; Brain; Chalcones; Flavonoids; Fluorides; Ligands; Male; Phosphates; Polycyclic Hydrocarbons, Aromatic; Rats; Rats, Wistar; Receptors, GABA-A; Salts

PY - 2008

Y1 - 2008

N2 - The synthesis of a series of derivatized flavylium cations was undertaken and the affinity to the benzodiazepine binding site of the GABA-A receptor evaluated. The observed high affinity for some derivatives (sub-muM range) was explained by an in vitro transformation of the flavylium cations into the corresponding trans-retrochalcones, components which are proposed to be the active species in this series.

AB - The synthesis of a series of derivatized flavylium cations was undertaken and the affinity to the benzodiazepine binding site of the GABA-A receptor evaluated. The observed high affinity for some derivatives (sub-muM range) was explained by an in vitro transformation of the flavylium cations into the corresponding trans-retrochalcones, components which are proposed to be the active species in this series.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.bmcl.2008.07.107

DO - 10.1016/j.bmcl.2008.07.107

M3 - Journal article

C2 - 18707883

VL - 18

SP - 4864

EP - 4867

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 17

ER -

ID: 10161334