Epithelial permeation and absorption mechanisms of biopharmaceuticals
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Delivery of biopharmaceuticals to local or systemic target sites via administration to mucosal surfaces is considered advantageous for several reasons, and is continuously explored by using optimized therapeutic molecules, novel excipients, and innovative formulation designs. However, the transport of biopharmaceuticals into and across epithelia in, for example, the airways and the intestine are limited due to their inherent instability and large molecular size. Thus, detailed knowledge about the properties of the epithelial barrier and the transport pathways that may be explored for delivery of peptides, proteins, and nucleotide-based drugs is a prerequisite for proper interpretation of the results of any experimental approach aiming at mucosal delivery of biopharmaceuticals. The present chapter describes the transport pathways and mechanisms relevant for epithelia in mucosal tissue providing examples of the drug delivery approaches taken to deliver biopharmaceuticals via the paracellular and/or transcellular pathways. Also, methodologies used to monitor and assess the delivery are critically discussed.
Original language | English |
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Title of host publication | Mucosal Delivery of Biopharmaceuticals : Biology, Challenges and Strategies |
Number of pages | 24 |
Volume | 9781461495246 |
Publisher | Springer US |
Publication date | 1 Oct 2014 |
Pages | 99-122 |
ISBN (Print) | 1461495237, 9781461495239 |
ISBN (Electronic) | 9781461495246 |
DOIs | |
Publication status | Published - 1 Oct 2014 |
- Analysis, Complexes, Lipid-based drug delivery systems, Paracellular transport, Particles, Pathway inhibitors, Permeability enhancers, Polymer-based drug delivery systems, Tight junction modulators, Transcellular transport, Transcytosis
Research areas
ID: 239817745