Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA): the Role of Solvent Type and Solvent Composition

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Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA) : the Role of Solvent Type and Solvent Composition. / Liu, Xiaoli; Baldursdottir, Stefania G; Aho, Johanna; Qu, Haiyan; Christensen, Lars Porskjær; Rantanen, Jukka; Yang, Mingshi.

In: Pharmaceutical Research, Vol. 34, No. 4, 04.2017, p. 738-749.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Liu, X, Baldursdottir, SG, Aho, J, Qu, H, Christensen, LP, Rantanen, J & Yang, M 2017, 'Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA): the Role of Solvent Type and Solvent Composition', Pharmaceutical Research, vol. 34, no. 4, pp. 738-749. https://doi.org/10.1007/s11095-017-2100-z

APA

Liu, X., Baldursdottir, S. G., Aho, J., Qu, H., Christensen, L. P., Rantanen, J., & Yang, M. (2017). Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA): the Role of Solvent Type and Solvent Composition. Pharmaceutical Research, 34(4), 738-749. https://doi.org/10.1007/s11095-017-2100-z

Vancouver

Liu X, Baldursdottir SG, Aho J, Qu H, Christensen LP, Rantanen J et al. Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA): the Role of Solvent Type and Solvent Composition. Pharmaceutical Research. 2017 Apr;34(4):738-749. https://doi.org/10.1007/s11095-017-2100-z

Author

Liu, Xiaoli ; Baldursdottir, Stefania G ; Aho, Johanna ; Qu, Haiyan ; Christensen, Lars Porskjær ; Rantanen, Jukka ; Yang, Mingshi. / Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA) : the Role of Solvent Type and Solvent Composition. In: Pharmaceutical Research. 2017 ; Vol. 34, No. 4. pp. 738-749.

Bibtex

@article{65673c602d6e42f08b73071698a53208,
title = "Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA): the Role of Solvent Type and Solvent Composition",
abstract = "PURPOSE: In this study, the electrospinnability of poly(lactic-co-glycolic acid) (PLGA) solutions was investigated, with a focus on understanding the influence of molecular weight of PLGA, solvent type and solvent composition on the physical properties of electrospun nanofibers.METHOD: Various solvents were tested to dissolve two PLGA grades (50 KDa-RG755, 100 KDa-RG750). The viscoelasticity, surface tension, and evaporation rate of the PLGA solutions were characterized prior to the electrospinning process. The resulting electrospun nanofibers were characterized with respect to the morphology and mechanical properties.RESULTS: Two pairs of solvent mixtures, i.e. dimethylformamide (DMF)-tetrahydrofuran (THF) and DMF-chloroform (CHL), were identified to provide a stable cone-jet. Within the polymer concentration range studied (10-30{\%}, w/v), RG750 solutions could be electrospun into uniform fibers at 30{\%} (w/v) or at 20{\%} (w/v) when modifying the solvent composition. In comparison to DMF-THF solution, fibers had larger diameter, higher stiffness and tensile strength when electrospun from DMF-CHL solution.CONCLUSION: The high molecular weight polymer could ensure sufficient intermolecular interaction to generate uniform fibers. The solvent could influence the morphology and mechanical properties of the electrospun fibers by altering the properties of PLGA solution, and drying rate of fibers in the electrospinning process.",
keywords = "Journal Article",
author = "Xiaoli Liu and Baldursdottir, {Stefania G} and Johanna Aho and Haiyan Qu and Christensen, {Lars Porskj{\ae}r} and Jukka Rantanen and Mingshi Yang",
year = "2017",
month = "4",
doi = "10.1007/s11095-017-2100-z",
language = "English",
volume = "34",
pages = "738--749",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Electrospinnability of Poly Lactic-co-glycolic Acid (PLGA)

T2 - the Role of Solvent Type and Solvent Composition

AU - Liu, Xiaoli

AU - Baldursdottir, Stefania G

AU - Aho, Johanna

AU - Qu, Haiyan

AU - Christensen, Lars Porskjær

AU - Rantanen, Jukka

AU - Yang, Mingshi

PY - 2017/4

Y1 - 2017/4

N2 - PURPOSE: In this study, the electrospinnability of poly(lactic-co-glycolic acid) (PLGA) solutions was investigated, with a focus on understanding the influence of molecular weight of PLGA, solvent type and solvent composition on the physical properties of electrospun nanofibers.METHOD: Various solvents were tested to dissolve two PLGA grades (50 KDa-RG755, 100 KDa-RG750). The viscoelasticity, surface tension, and evaporation rate of the PLGA solutions were characterized prior to the electrospinning process. The resulting electrospun nanofibers were characterized with respect to the morphology and mechanical properties.RESULTS: Two pairs of solvent mixtures, i.e. dimethylformamide (DMF)-tetrahydrofuran (THF) and DMF-chloroform (CHL), were identified to provide a stable cone-jet. Within the polymer concentration range studied (10-30%, w/v), RG750 solutions could be electrospun into uniform fibers at 30% (w/v) or at 20% (w/v) when modifying the solvent composition. In comparison to DMF-THF solution, fibers had larger diameter, higher stiffness and tensile strength when electrospun from DMF-CHL solution.CONCLUSION: The high molecular weight polymer could ensure sufficient intermolecular interaction to generate uniform fibers. The solvent could influence the morphology and mechanical properties of the electrospun fibers by altering the properties of PLGA solution, and drying rate of fibers in the electrospinning process.

AB - PURPOSE: In this study, the electrospinnability of poly(lactic-co-glycolic acid) (PLGA) solutions was investigated, with a focus on understanding the influence of molecular weight of PLGA, solvent type and solvent composition on the physical properties of electrospun nanofibers.METHOD: Various solvents were tested to dissolve two PLGA grades (50 KDa-RG755, 100 KDa-RG750). The viscoelasticity, surface tension, and evaporation rate of the PLGA solutions were characterized prior to the electrospinning process. The resulting electrospun nanofibers were characterized with respect to the morphology and mechanical properties.RESULTS: Two pairs of solvent mixtures, i.e. dimethylformamide (DMF)-tetrahydrofuran (THF) and DMF-chloroform (CHL), were identified to provide a stable cone-jet. Within the polymer concentration range studied (10-30%, w/v), RG750 solutions could be electrospun into uniform fibers at 30% (w/v) or at 20% (w/v) when modifying the solvent composition. In comparison to DMF-THF solution, fibers had larger diameter, higher stiffness and tensile strength when electrospun from DMF-CHL solution.CONCLUSION: The high molecular weight polymer could ensure sufficient intermolecular interaction to generate uniform fibers. The solvent could influence the morphology and mechanical properties of the electrospun fibers by altering the properties of PLGA solution, and drying rate of fibers in the electrospinning process.

KW - Journal Article

U2 - 10.1007/s11095-017-2100-z

DO - 10.1007/s11095-017-2100-z

M3 - Journal article

VL - 34

SP - 738

EP - 749

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 4

ER -

ID: 174935972