Electromembrane extraction of polar substances – Status and perspectives
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Electromembrane extraction of polar substances – Status and perspectives. / Eie, Linda Vårdal; Pedersen-Bjergaard, Stig; Hansen, Frederik André.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 207, 114407, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Electromembrane extraction of polar substances – Status and perspectives
AU - Eie, Linda Vårdal
AU - Pedersen-Bjergaard, Stig
AU - Hansen, Frederik André
N1 - Publisher Copyright: © 2021 The Authors
PY - 2022
Y1 - 2022
N2 - In this article, the scientific literature on electromembrane extraction (EME) of polar substances (log P < 2) is reviewed. EME is an extraction technique based on electrokinetic migration of analyte ions from an aqueous sample, across an organic supported liquid membrane (SLM), and into an aqueous acceptor solution. Because extraction is based on voltage-assisted partitioning, EME is fundamentally suitable for extraction of polar and ionizable substances that are challenging in many other extraction techniques. The article provides an exhaustive overview of papers on EME of polar substances. From this, different strategies to improve the mass transfer of polar substances are reviewed and critically discussed. These strategies include different SLM chemistries, modification of supporting membranes, sorbent additives, aqueous solution chemistry, and voltage/current related strategies. Finally, the future applicability of EME for polar substances is discussed. We expect EME in the coming years to be developed towards both very selective targeted analysis, as well as untargeted analysis of polar substances in biomedical applications such as metabolomics and peptidomics.
AB - In this article, the scientific literature on electromembrane extraction (EME) of polar substances (log P < 2) is reviewed. EME is an extraction technique based on electrokinetic migration of analyte ions from an aqueous sample, across an organic supported liquid membrane (SLM), and into an aqueous acceptor solution. Because extraction is based on voltage-assisted partitioning, EME is fundamentally suitable for extraction of polar and ionizable substances that are challenging in many other extraction techniques. The article provides an exhaustive overview of papers on EME of polar substances. From this, different strategies to improve the mass transfer of polar substances are reviewed and critically discussed. These strategies include different SLM chemistries, modification of supporting membranes, sorbent additives, aqueous solution chemistry, and voltage/current related strategies. Finally, the future applicability of EME for polar substances is discussed. We expect EME in the coming years to be developed towards both very selective targeted analysis, as well as untargeted analysis of polar substances in biomedical applications such as metabolomics and peptidomics.
KW - Electromembrane extraction
KW - Microextraction
KW - Polar substances
KW - Review
KW - Sample preparation
KW - Supported liquid membranes
U2 - 10.1016/j.jpba.2021.114407
DO - 10.1016/j.jpba.2021.114407
M3 - Journal article
C2 - 34634529
AN - SCOPUS:85116570533
VL - 207
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
SN - 0731-7085
M1 - 114407
ER -
ID: 287758973