Elastin-derived peptides are new regulators of insulin resistance development in mice

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Elastin-derived peptides are new regulators of insulin resistance development in mice. / Blaise, Sébastien; Romier, Béatrice; Kawecki, Charlotte; Ghirardi, Maxime; Rabenoelina, Fanja; Baud, Stéphanie; Duca, Laurent; Maurice, Pascal; Heinz, Andrea; Schmelzer, Christian E H; Tarpin, Michel; Martiny, Laurent; Garbar, Christian; Dauchez, Manuel; Debelle, Laurent; Durlach, Vincent.

In: Diabetes, Vol. 62, No. 11, 11.2013, p. 3807-16.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Blaise, S, Romier, B, Kawecki, C, Ghirardi, M, Rabenoelina, F, Baud, S, Duca, L, Maurice, P, Heinz, A, Schmelzer, CEH, Tarpin, M, Martiny, L, Garbar, C, Dauchez, M, Debelle, L & Durlach, V 2013, 'Elastin-derived peptides are new regulators of insulin resistance development in mice', Diabetes, vol. 62, no. 11, pp. 3807-16. https://doi.org/10.2337/db13-0508

APA

Blaise, S., Romier, B., Kawecki, C., Ghirardi, M., Rabenoelina, F., Baud, S., Duca, L., Maurice, P., Heinz, A., Schmelzer, C. E. H., Tarpin, M., Martiny, L., Garbar, C., Dauchez, M., Debelle, L., & Durlach, V. (2013). Elastin-derived peptides are new regulators of insulin resistance development in mice. Diabetes, 62(11), 3807-16. https://doi.org/10.2337/db13-0508

Vancouver

Blaise S, Romier B, Kawecki C, Ghirardi M, Rabenoelina F, Baud S et al. Elastin-derived peptides are new regulators of insulin resistance development in mice. Diabetes. 2013 Nov;62(11):3807-16. https://doi.org/10.2337/db13-0508

Author

Blaise, Sébastien ; Romier, Béatrice ; Kawecki, Charlotte ; Ghirardi, Maxime ; Rabenoelina, Fanja ; Baud, Stéphanie ; Duca, Laurent ; Maurice, Pascal ; Heinz, Andrea ; Schmelzer, Christian E H ; Tarpin, Michel ; Martiny, Laurent ; Garbar, Christian ; Dauchez, Manuel ; Debelle, Laurent ; Durlach, Vincent. / Elastin-derived peptides are new regulators of insulin resistance development in mice. In: Diabetes. 2013 ; Vol. 62, No. 11. pp. 3807-16.

Bibtex

@article{542fe56994b64d338fe7d5c02f146769,
title = "Elastin-derived peptides are new regulators of insulin resistance development in mice",
abstract = "Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also been demonstrated to play an important role in cell physiology and the development of cardiovascular and metabolic diseases. In the current study, we show that elastin-derived peptides (EDPs) may be involved in the development of insulin resistance (IRES) in mice. In chow-fed mice, acute or chronic intravenous injections of EDPs induced hyperglycemic effects associated with glucose uptake reduction and IRES in skeletal muscle, liver, and adipose tissue. Based on in vivo, in vitro, and in silico approaches, we propose that this IRES is due to interaction between the insulin receptor (IR) and the neuraminidase-1 subunit of the elastin receptor complex triggered by EDPs. This interplay was correlated with decreased sialic acid levels on the β-chain of the IR and reduction of IR signaling. In conclusion, this is the first study to demonstrate that EDPs, which mainly accumulate with aging, may be involved in the insidious development of IRES.",
keywords = "Animals, Elastin, Energy Metabolism, Hyperglycemia, Insulin Resistance, Male, Mice, Mice, Inbred C57BL, N-Acetylneuraminic Acid, Neuraminidase, Oligopeptides, Peptide Fragments, Receptor, Insulin, Receptors, Cell Surface, Journal Article, Research Support, Non-U.S. Gov't",
author = "S{\'e}bastien Blaise and B{\'e}atrice Romier and Charlotte Kawecki and Maxime Ghirardi and Fanja Rabenoelina and St{\'e}phanie Baud and Laurent Duca and Pascal Maurice and Andrea Heinz and Schmelzer, {Christian E H} and Michel Tarpin and Laurent Martiny and Christian Garbar and Manuel Dauchez and Laurent Debelle and Vincent Durlach",
year = "2013",
month = nov,
doi = "10.2337/db13-0508",
language = "English",
volume = "62",
pages = "3807--16",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "11",

}

RIS

TY - JOUR

T1 - Elastin-derived peptides are new regulators of insulin resistance development in mice

AU - Blaise, Sébastien

AU - Romier, Béatrice

AU - Kawecki, Charlotte

AU - Ghirardi, Maxime

AU - Rabenoelina, Fanja

AU - Baud, Stéphanie

AU - Duca, Laurent

AU - Maurice, Pascal

AU - Heinz, Andrea

AU - Schmelzer, Christian E H

AU - Tarpin, Michel

AU - Martiny, Laurent

AU - Garbar, Christian

AU - Dauchez, Manuel

AU - Debelle, Laurent

AU - Durlach, Vincent

PY - 2013/11

Y1 - 2013/11

N2 - Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also been demonstrated to play an important role in cell physiology and the development of cardiovascular and metabolic diseases. In the current study, we show that elastin-derived peptides (EDPs) may be involved in the development of insulin resistance (IRES) in mice. In chow-fed mice, acute or chronic intravenous injections of EDPs induced hyperglycemic effects associated with glucose uptake reduction and IRES in skeletal muscle, liver, and adipose tissue. Based on in vivo, in vitro, and in silico approaches, we propose that this IRES is due to interaction between the insulin receptor (IR) and the neuraminidase-1 subunit of the elastin receptor complex triggered by EDPs. This interplay was correlated with decreased sialic acid levels on the β-chain of the IR and reduction of IR signaling. In conclusion, this is the first study to demonstrate that EDPs, which mainly accumulate with aging, may be involved in the insidious development of IRES.

AB - Although it has long been established that the extracellular matrix acts as a mechanical support, its degradation products, which mainly accumulate during aging, have also been demonstrated to play an important role in cell physiology and the development of cardiovascular and metabolic diseases. In the current study, we show that elastin-derived peptides (EDPs) may be involved in the development of insulin resistance (IRES) in mice. In chow-fed mice, acute or chronic intravenous injections of EDPs induced hyperglycemic effects associated with glucose uptake reduction and IRES in skeletal muscle, liver, and adipose tissue. Based on in vivo, in vitro, and in silico approaches, we propose that this IRES is due to interaction between the insulin receptor (IR) and the neuraminidase-1 subunit of the elastin receptor complex triggered by EDPs. This interplay was correlated with decreased sialic acid levels on the β-chain of the IR and reduction of IR signaling. In conclusion, this is the first study to demonstrate that EDPs, which mainly accumulate with aging, may be involved in the insidious development of IRES.

KW - Animals

KW - Elastin

KW - Energy Metabolism

KW - Hyperglycemia

KW - Insulin Resistance

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - N-Acetylneuraminic Acid

KW - Neuraminidase

KW - Oligopeptides

KW - Peptide Fragments

KW - Receptor, Insulin

KW - Receptors, Cell Surface

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.2337/db13-0508

DO - 10.2337/db13-0508

M3 - Journal article

C2 - 23919962

VL - 62

SP - 3807

EP - 3816

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 11

ER -

ID: 186422105