Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols

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Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols. / Mu, Huiling; Høy, Carl-Erik.

In: Lipids, Vol. 35, No. 1, 01.01.2000, p. 83-89.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mu, H & Høy, C-E 2000, 'Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols', Lipids, vol. 35, no. 1, pp. 83-89.

APA

Mu, H., & Høy, C-E. (2000). Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols. Lipids, 35(1), 83-89.

Vancouver

Mu H, Høy C-E. Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols. Lipids. 2000 Jan 1;35(1):83-89.

Author

Mu, Huiling ; Høy, Carl-Erik. / Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols. In: Lipids. 2000 ; Vol. 35, No. 1. pp. 83-89.

Bibtex

@article{4c46817e976b4ac8a69d4e21bf8c2b9d,
title = "Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols",
abstract = "To study the effect of the chain length of medium-chain fatty acids on the intestinal absorption of long-chain fatty acids, we examined the lymphatic transport of fat following administration of five purified structured triacylglycerols (STAG) containing different medium-chain fatty acids in the sn-1,3 positions and long-chain fatty acids in the sn-2 position in a rat model. Significant amounts of medium-chain fatty acids were found in lymph samples after intragastric administration of 1,3-dioctanoyl-2-linoleyl- sn-glycerol (8:0/18:2/8:0), 1,3-didecanoyl-2-linoleyl-sn-glycerol, and 1,3- didodecanoyl-2-linoleyl-sn-glycerol. The accumulated lymphatic transport of medium-chain fatty acids increased with increasing carbon chain length. The recoveries of caprylic acid (8:0), capric acid (10:0), and lauric acid (12:0) were 7.3 ± 0.9, 26.3 ± 2.4, and 81.7 ± 6.9%, respectively. No significant differences were observed for the maximal intestinal absorption of linoleic acid (18:2n-6) when the chain length of medium-chain fatty acids at the primary positions was varied, and the absorption of 18:2 and oleic acid (18:1) from 8:0/18:2/8:0 and 1,3-dioctanoyl-2-oleyl-sn-glycerol was similar. We conclude that the chain length of the medium-chain fatty acids in the primary positions of STAG does not affect the maximal intestinal absorption of long-chain fatty acids in the sn-2 position in the applied rat model, whereas the distribution of fatty acids between the lymphatics and the portal vein reflects the chain length of the fatty acids.",
author = "Huiling Mu and Carl-Erik H{\o}y",
year = "2000",
month = jan,
day = "1",
language = "English",
volume = "35",
pages = "83--89",
journal = "Lipids",
issn = "0024-4201",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols

AU - Mu, Huiling

AU - Høy, Carl-Erik

PY - 2000/1/1

Y1 - 2000/1/1

N2 - To study the effect of the chain length of medium-chain fatty acids on the intestinal absorption of long-chain fatty acids, we examined the lymphatic transport of fat following administration of five purified structured triacylglycerols (STAG) containing different medium-chain fatty acids in the sn-1,3 positions and long-chain fatty acids in the sn-2 position in a rat model. Significant amounts of medium-chain fatty acids were found in lymph samples after intragastric administration of 1,3-dioctanoyl-2-linoleyl- sn-glycerol (8:0/18:2/8:0), 1,3-didecanoyl-2-linoleyl-sn-glycerol, and 1,3- didodecanoyl-2-linoleyl-sn-glycerol. The accumulated lymphatic transport of medium-chain fatty acids increased with increasing carbon chain length. The recoveries of caprylic acid (8:0), capric acid (10:0), and lauric acid (12:0) were 7.3 ± 0.9, 26.3 ± 2.4, and 81.7 ± 6.9%, respectively. No significant differences were observed for the maximal intestinal absorption of linoleic acid (18:2n-6) when the chain length of medium-chain fatty acids at the primary positions was varied, and the absorption of 18:2 and oleic acid (18:1) from 8:0/18:2/8:0 and 1,3-dioctanoyl-2-oleyl-sn-glycerol was similar. We conclude that the chain length of the medium-chain fatty acids in the primary positions of STAG does not affect the maximal intestinal absorption of long-chain fatty acids in the sn-2 position in the applied rat model, whereas the distribution of fatty acids between the lymphatics and the portal vein reflects the chain length of the fatty acids.

AB - To study the effect of the chain length of medium-chain fatty acids on the intestinal absorption of long-chain fatty acids, we examined the lymphatic transport of fat following administration of five purified structured triacylglycerols (STAG) containing different medium-chain fatty acids in the sn-1,3 positions and long-chain fatty acids in the sn-2 position in a rat model. Significant amounts of medium-chain fatty acids were found in lymph samples after intragastric administration of 1,3-dioctanoyl-2-linoleyl- sn-glycerol (8:0/18:2/8:0), 1,3-didecanoyl-2-linoleyl-sn-glycerol, and 1,3- didodecanoyl-2-linoleyl-sn-glycerol. The accumulated lymphatic transport of medium-chain fatty acids increased with increasing carbon chain length. The recoveries of caprylic acid (8:0), capric acid (10:0), and lauric acid (12:0) were 7.3 ± 0.9, 26.3 ± 2.4, and 81.7 ± 6.9%, respectively. No significant differences were observed for the maximal intestinal absorption of linoleic acid (18:2n-6) when the chain length of medium-chain fatty acids at the primary positions was varied, and the absorption of 18:2 and oleic acid (18:1) from 8:0/18:2/8:0 and 1,3-dioctanoyl-2-oleyl-sn-glycerol was similar. We conclude that the chain length of the medium-chain fatty acids in the primary positions of STAG does not affect the maximal intestinal absorption of long-chain fatty acids in the sn-2 position in the applied rat model, whereas the distribution of fatty acids between the lymphatics and the portal vein reflects the chain length of the fatty acids.

UR - http://www.scopus.com/inward/record.url?scp=0033981094&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0033981094

VL - 35

SP - 83

EP - 89

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 1

ER -

ID: 45572614