Effective modification of particle surface properties using ultrasonic water mist.
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Effective modification of particle surface properties using ultrasonic water mist. / Genina, Natalja; Räikkönen, Heikki; Heinämäki, Jyrki; Antikainen, Osmo; Siiriä, Simo; Veski, Peep; Yliruusi, Jouko.
In: AAPS PharmSciTech, Vol. 10, No. 1, 2009, p. 282-288.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Effective modification of particle surface properties using ultrasonic water mist.
AU - Genina, Natalja
AU - Räikkönen, Heikki
AU - Heinämäki, Jyrki
AU - Antikainen, Osmo
AU - Siiriä, Simo
AU - Veski, Peep
AU - Yliruusi, Jouko
PY - 2009
Y1 - 2009
N2 - The goal of the present study was to design a new technique to modify particle surface properties and, through that, to improve flowability of poorly flowing drug thiamine hydrochloride and pharmaceutical sugar lactose monohydrate of two different grades. The powdered particles were supplied by a vibratory feeder and exposed to an instantaneous effect of water mist generated from an ultrasound nebulizer. The processed and original powders were evaluated with respect to morphology (scanning electron microscopy, atomic force microscopy, and spatial filtering technique), flow, and solid state properties. It was found that rapid exposition of pharmaceutical materials by water mist resulted in the improvement of powder technical properties. The evident changes in flowability of coarser lactose were obviously due to smoothing of particle surface and decreasing in the level of fines with very slight increment in particle size. The changes in thiamine powder flow were mainly due to narrowing in particle size distribution where the tendency for better flow of finer lactose was related to surface and size modifications. The aqueous mist application did not cause any alteration of the crystal structures of the studied materials. The proposed water mist treatment technique appears to be a robust, rapid, and promising tool for the improvement of the technological properties of pharmaceutical powders.
AB - The goal of the present study was to design a new technique to modify particle surface properties and, through that, to improve flowability of poorly flowing drug thiamine hydrochloride and pharmaceutical sugar lactose monohydrate of two different grades. The powdered particles were supplied by a vibratory feeder and exposed to an instantaneous effect of water mist generated from an ultrasound nebulizer. The processed and original powders were evaluated with respect to morphology (scanning electron microscopy, atomic force microscopy, and spatial filtering technique), flow, and solid state properties. It was found that rapid exposition of pharmaceutical materials by water mist resulted in the improvement of powder technical properties. The evident changes in flowability of coarser lactose were obviously due to smoothing of particle surface and decreasing in the level of fines with very slight increment in particle size. The changes in thiamine powder flow were mainly due to narrowing in particle size distribution where the tendency for better flow of finer lactose was related to surface and size modifications. The aqueous mist application did not cause any alteration of the crystal structures of the studied materials. The proposed water mist treatment technique appears to be a robust, rapid, and promising tool for the improvement of the technological properties of pharmaceutical powders.
KW - fl ow properties
KW - lactose monohydrate
KW - surface properties
KW - thiamine hydrochloride
KW - ultrasonic water mist
U2 - 10.1208/s12249-009-9208-3
DO - 10.1208/s12249-009-9208-3
M3 - Journal article
C2 - 19288203
VL - 10
SP - 282
EP - 288
JO - AAPS PharmSciTech
JF - AAPS PharmSciTech
SN - 1530-9932
IS - 1
ER -
ID: 145539119