Effect of trefoil factors on the viscoelastic properties of mucus gels
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Effect of trefoil factors on the viscoelastic properties of mucus gels. / Thim, L; Madsen, F; Poulsen, S S; Poulsen, Steen Seier.
In: European Journal of Clinical Investigation, Vol. 32, No. 7, 01.07.2002, p. 519-27.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of trefoil factors on the viscoelastic properties of mucus gels
AU - Thim, L
AU - Madsen, F
AU - Poulsen, S S
AU - Poulsen, Steen Seier
PY - 2002/7/1
Y1 - 2002/7/1
N2 - Trefoil peptides (TFFs) are expressed and secreted in a tissue-specific manner in the gastrointestinal tract. Evidence of coexpression of trefoil peptides and mucins has been demonstrated in most mucus-producing cells in the gastrointestinal tract. The expression of trefoil peptides is up-regulated in gastric ulceration and colitis. It is believed that TFF peptides interact with mucin to increase viscosity but this has never been confirmed. The aims of the present study were to elucidate the direct effect of trefoil peptides on mucus gel formation.
AB - Trefoil peptides (TFFs) are expressed and secreted in a tissue-specific manner in the gastrointestinal tract. Evidence of coexpression of trefoil peptides and mucins has been demonstrated in most mucus-producing cells in the gastrointestinal tract. The expression of trefoil peptides is up-regulated in gastric ulceration and colitis. It is believed that TFF peptides interact with mucin to increase viscosity but this has never been confirmed. The aims of the present study were to elucidate the direct effect of trefoil peptides on mucus gel formation.
KW - Animals
KW - Cattle
KW - Elasticity
KW - Gels
KW - Growth Substances
KW - Humans
KW - Immunohistochemistry
KW - Mucins
KW - Muscle Proteins
KW - Neuropeptides
KW - Peptides
KW - Proteins
KW - Rheology
KW - Sputum
KW - Swine
KW - Tumor Suppressor Proteins
KW - Viscosity
M3 - Journal article
C2 - 12153553
VL - 32
SP - 519
EP - 527
JO - Zeitschrift fur klinische Medizin
JF - Zeitschrift fur klinische Medizin
SN - 0014-2972
IS - 7
ER -
ID: 33793046