Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration

Research output: Contribution to journalJournal articleResearchpeer-review

  • Wenli Liu
  • Xiaona Wang
  • Ruilian Chen
  • Kaixuan Zhang
  • Yao Li
  • Yi Li
  • Duanyun Si
  • Junbo Gong
  • Dianshu Yin
  • Yongli Wang
  • Zhenping Wei
  • Yang, Mingshi

The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration. However, no systemic investigations have been made on the change of this pharmacokinetic difference, resulted either from the physiological or from the pathological factors. In this paper, we used polymorphic nimodipine (Nim) as a model drug and investigated the effect of age difference (2- and 9-month old) on the pharmacokinetics after oral delivery in rats. As the results shown, for L-form of Nim (L-Nim), the AUC0-24 h in 2-month-old rats was 343.68±47.15 ng·h/mL, which is 23.36% higher than that in 9-month-old rats. For H-form of Nim (H-Nim), the AUC0-24 h in 2-month-old rats was 140.91±19.47 ng·h/mL, which is 54.64% higher than that in 9-month-old rats. The AUC0-24 h ratio between H-Nim and L-Nim was 2.44 in 2-month-old rats and 3.06 in 9-month-old rats. Since age difference could result in unparallelled change of the absorption and bioavailability of the polymorphic drugs, the results in this experiment are of value for further investigation of crystal form selection in clinical trials and rational clinical application of the polymorphic drugs.

Original languageEnglish
JournalActa Pharmaceutica Sinica B
Issue number5
Pages (from-to)468-474
Number of pages7
Publication statusPublished - Sep 2016

ID: 169358866