Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging. / Ye, Fengbin; Larsen, Susan Weng; Yaghmur, Anan; Jensen, Henrik; Larsen, Claus Selch; Ostergaard, Jesper.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 71, 2012, p. 27-34.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ye, F, Larsen, SW, Yaghmur, A, Jensen, H, Larsen, CS & Ostergaard, J 2012, 'Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging', Journal of Pharmaceutical and Biomedical Analysis, vol. 71, pp. 27-34. https://doi.org/10.1016/j.jpba.2012.07.024

APA

Ye, F., Larsen, S. W., Yaghmur, A., Jensen, H., Larsen, C. S., & Ostergaard, J. (2012). Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging. Journal of Pharmaceutical and Biomedical Analysis, 71, 27-34. https://doi.org/10.1016/j.jpba.2012.07.024

Vancouver

Ye F, Larsen SW, Yaghmur A, Jensen H, Larsen CS, Ostergaard J. Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging. Journal of Pharmaceutical and Biomedical Analysis. 2012;71:27-34. https://doi.org/10.1016/j.jpba.2012.07.024

Author

Ye, Fengbin ; Larsen, Susan Weng ; Yaghmur, Anan ; Jensen, Henrik ; Larsen, Claus Selch ; Ostergaard, Jesper. / Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging. In: Journal of Pharmaceutical and Biomedical Analysis. 2012 ; Vol. 71. pp. 27-34.

Bibtex

@article{306f19c0620d43348e69647d6ca5a5af,

title = "Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging",

abstract = "Upon subcutaneous administration, the distribution of drug between the delivery vehicle and the biological tissue critically affects the absorption of drug substances. Utilization of physical models resembling the native tissues appears promising for obtaining a detailed understanding of the performance of drug delivery systems based on in vitro experiments. The objective of this study was to evaluate a UV imaging-based method for real-time characterization of the release and transport of piroxicam in hydrogel-based subcutaneous tissue mimics/surrogates. Piroxicam partitioning from medium chain triglyceride (MCT) into 0.5% (w/v) agarose or 25% (w/v) F127-based hydrogels was investigated by monitoring the concentration profiles of the drug in the gels. The effect of pH on piroxicam distribution and diffusion coefficients was studied. For both hydrogel systems, the diffusion of piroxicam in the gels was not affected significantly by the pH change from 4.0 to 7.4 but a considerable change in the oil-gel distribution coefficients was found (24 and 34 times less at pH 7.4 as compared those observed at pH 4.0 for F127 and agarose gels, respectively). In addition, the release and transport processes of piroxicam upon the injection of aqueous or MCT solutions into an agarose-based hydrogel were investigated by UV imaging. The spatial distribution of piroxicam around the injection site in the gel matrix was monitored in real-time. The disappearance profiles of piroxicam from the injected aqueous solution were obtained. This study shows that the UV imaging methodology has considerable potential for characterizing transport properties in hydrogels, including monitoring the real-time spatial concentration distribution in vitro after administration by injection.",

author = "Fengbin Ye and Larsen, {Susan Weng} and Anan Yaghmur and Henrik Jensen and Larsen, {Claus Selch} and Jesper Ostergaard",

year = "2012",

doi = "10.1016/j.jpba.2012.07.024",

language = "English",

volume = "71",

pages = "27--34",

journal = "Journal of Pharmaceutical and Biomedical Analysis",

issn = "0731-7085",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Drug release into hydrogel-based subcutaneous surrogates studied by UV imaging

AU - Ye, Fengbin

AU - Larsen, Susan Weng

AU - Yaghmur, Anan

AU - Jensen, Henrik

AU - Larsen, Claus Selch

AU - Ostergaard, Jesper

PY - 2012

Y1 - 2012

N2 - Upon subcutaneous administration, the distribution of drug between the delivery vehicle and the biological tissue critically affects the absorption of drug substances. Utilization of physical models resembling the native tissues appears promising for obtaining a detailed understanding of the performance of drug delivery systems based on in vitro experiments. The objective of this study was to evaluate a UV imaging-based method for real-time characterization of the release and transport of piroxicam in hydrogel-based subcutaneous tissue mimics/surrogates. Piroxicam partitioning from medium chain triglyceride (MCT) into 0.5% (w/v) agarose or 25% (w/v) F127-based hydrogels was investigated by monitoring the concentration profiles of the drug in the gels. The effect of pH on piroxicam distribution and diffusion coefficients was studied. For both hydrogel systems, the diffusion of piroxicam in the gels was not affected significantly by the pH change from 4.0 to 7.4 but a considerable change in the oil-gel distribution coefficients was found (24 and 34 times less at pH 7.4 as compared those observed at pH 4.0 for F127 and agarose gels, respectively). In addition, the release and transport processes of piroxicam upon the injection of aqueous or MCT solutions into an agarose-based hydrogel were investigated by UV imaging. The spatial distribution of piroxicam around the injection site in the gel matrix was monitored in real-time. The disappearance profiles of piroxicam from the injected aqueous solution were obtained. This study shows that the UV imaging methodology has considerable potential for characterizing transport properties in hydrogels, including monitoring the real-time spatial concentration distribution in vitro after administration by injection.

AB - Upon subcutaneous administration, the distribution of drug between the delivery vehicle and the biological tissue critically affects the absorption of drug substances. Utilization of physical models resembling the native tissues appears promising for obtaining a detailed understanding of the performance of drug delivery systems based on in vitro experiments. The objective of this study was to evaluate a UV imaging-based method for real-time characterization of the release and transport of piroxicam in hydrogel-based subcutaneous tissue mimics/surrogates. Piroxicam partitioning from medium chain triglyceride (MCT) into 0.5% (w/v) agarose or 25% (w/v) F127-based hydrogels was investigated by monitoring the concentration profiles of the drug in the gels. The effect of pH on piroxicam distribution and diffusion coefficients was studied. For both hydrogel systems, the diffusion of piroxicam in the gels was not affected significantly by the pH change from 4.0 to 7.4 but a considerable change in the oil-gel distribution coefficients was found (24 and 34 times less at pH 7.4 as compared those observed at pH 4.0 for F127 and agarose gels, respectively). In addition, the release and transport processes of piroxicam upon the injection of aqueous or MCT solutions into an agarose-based hydrogel were investigated by UV imaging. The spatial distribution of piroxicam around the injection site in the gel matrix was monitored in real-time. The disappearance profiles of piroxicam from the injected aqueous solution were obtained. This study shows that the UV imaging methodology has considerable potential for characterizing transport properties in hydrogels, including monitoring the real-time spatial concentration distribution in vitro after administration by injection.

U2 - 10.1016/j.jpba.2012.07.024

DO - 10.1016/j.jpba.2012.07.024

M3 - Journal article

C2 - 22889608

VL - 71

SP - 27

EP - 34

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

SN - 0731-7085

ER -

ID: 40849321

Department of Pharmacy