Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers. / Nielsen, H. Mørck; Brøndsted, H.; Frokjaer, S.; Hovgaard, L.

In: S.T.P. Pharma Sciences, Vol. 6, No. 2, 01.03.1996, p. 157-161.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, HM, Brøndsted, H, Frokjaer, S & Hovgaard, L 1996, 'Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers', S.T.P. Pharma Sciences, vol. 6, no. 2, pp. 157-161.

APA

Nielsen, H. M., Brøndsted, H., Frokjaer, S., & Hovgaard, L. (1996). Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers. S.T.P. Pharma Sciences, 6(2), 157-161.

Vancouver

Nielsen HM, Brøndsted H, Frokjaer S, Hovgaard L. Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers. S.T.P. Pharma Sciences. 1996 Mar 1;6(2):157-161.

Author

Nielsen, H. Mørck ; Brøndsted, H. ; Frokjaer, S. ; Hovgaard, L. / Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers. In: S.T.P. Pharma Sciences. 1996 ; Vol. 6, No. 2. pp. 157-161.

Bibtex

@article{8fcf54337d954d848a463690475c7ffd,
title = "Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers",
abstract = "In this study, the absorption enhancing ability of a group of a unique series of fatty acid derivatives, ethyl glucoside esters, was evaluated. Esters of saturated C10-C18 fatty acids as well as an ester derivative of the unsaturated oleic acid were included in the study. Caco-2 monolayers were used as a model for the human intestinal epithelium. The effect of the ethyl glucoside esters on the intracellular dehydrogenase activity was determined using a staining method based on thiazolyl blue reduction, and cytoplasmic staining with trypan blue was used to characterize the degree of membrane perturbation caused by ethyl glucoside esters. It was found that ethyl glucoside esters of C10 and C12 fatty acids as well as the ester of oleic acid enhanced the penetration of a hydrophilic pore marker (PEG 4000) across the Caco-2 monolayers. The apparent permeability coefficient increased even at concentrations of ethyl glucoside esters which only showed minor toxic effects on the Caco-2 monolayers.",
keywords = "Absorption enhancer, Acylglucoside, Caco-2, Cell culture, Ethyl glucoside ester, Intestinal permeability",
author = "Nielsen, {H. M{\o}rck} and H. Br{\o}ndsted and S. Frokjaer and L. Hovgaard",
year = "1996",
month = mar,
day = "1",
language = "English",
volume = "6",
pages = "157--161",
journal = "STP pharma sciences",
issn = "1157-1489",
publisher = "Editions de Sante",
number = "2",

}

RIS

TY - JOUR

T1 - Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers

AU - Nielsen, H. Mørck

AU - Brøndsted, H.

AU - Frokjaer, S.

AU - Hovgaard, L.

PY - 1996/3/1

Y1 - 1996/3/1

N2 - In this study, the absorption enhancing ability of a group of a unique series of fatty acid derivatives, ethyl glucoside esters, was evaluated. Esters of saturated C10-C18 fatty acids as well as an ester derivative of the unsaturated oleic acid were included in the study. Caco-2 monolayers were used as a model for the human intestinal epithelium. The effect of the ethyl glucoside esters on the intracellular dehydrogenase activity was determined using a staining method based on thiazolyl blue reduction, and cytoplasmic staining with trypan blue was used to characterize the degree of membrane perturbation caused by ethyl glucoside esters. It was found that ethyl glucoside esters of C10 and C12 fatty acids as well as the ester of oleic acid enhanced the penetration of a hydrophilic pore marker (PEG 4000) across the Caco-2 monolayers. The apparent permeability coefficient increased even at concentrations of ethyl glucoside esters which only showed minor toxic effects on the Caco-2 monolayers.

AB - In this study, the absorption enhancing ability of a group of a unique series of fatty acid derivatives, ethyl glucoside esters, was evaluated. Esters of saturated C10-C18 fatty acids as well as an ester derivative of the unsaturated oleic acid were included in the study. Caco-2 monolayers were used as a model for the human intestinal epithelium. The effect of the ethyl glucoside esters on the intracellular dehydrogenase activity was determined using a staining method based on thiazolyl blue reduction, and cytoplasmic staining with trypan blue was used to characterize the degree of membrane perturbation caused by ethyl glucoside esters. It was found that ethyl glucoside esters of C10 and C12 fatty acids as well as the ester of oleic acid enhanced the penetration of a hydrophilic pore marker (PEG 4000) across the Caco-2 monolayers. The apparent permeability coefficient increased even at concentrations of ethyl glucoside esters which only showed minor toxic effects on the Caco-2 monolayers.

KW - Absorption enhancer

KW - Acylglucoside

KW - Caco-2

KW - Cell culture

KW - Ethyl glucoside ester

KW - Intestinal permeability

UR - http://www.scopus.com/inward/record.url?scp=0029883211&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0029883211

VL - 6

SP - 157

EP - 161

JO - STP pharma sciences

JF - STP pharma sciences

SN - 1157-1489

IS - 2

ER -

ID: 239817359