Distribution of binder in granules produced by means of twin screw granulation
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Distribution of binder in granules produced by means of twin screw granulation. / Fonteyne, Margot; Fussell, Andrew Luke; Vercruysse, Jurgen; Vervaet, Chris; Remon, Jean Paul; Strachan, Clare; Rades, Thomas; De Beer, Thomas.
In: International Journal of Pharmaceutics, Vol. 462, No. 1-2, 28.02.2014, p. 8-10.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Distribution of binder in granules produced by means of twin screw granulation
AU - Fonteyne, Margot
AU - Fussell, Andrew Luke
AU - Vercruysse, Jurgen
AU - Vervaet, Chris
AU - Remon, Jean Paul
AU - Strachan, Clare
AU - Rades, Thomas
AU - De Beer, Thomas
N1 - Copyright © 2013 Elsevier B.V. All rights reserved.
PY - 2014/2/28
Y1 - 2014/2/28
N2 - According to the quality by design principle processes may not remain black-boxes and full process understanding is required. The granule size distribution of granules produced via twin screw granulation is often found to be bimodal. The aim of this study was to gain a better understanding of binder distribution within granules produced via twin screw granulation in order to investigate if an inhomogeneous spread of binder is causing this bimodal size distribution. Theophylline-lactose-polyvinylpyrrolidone K30 (PVP) (30-67.5-2.5%, w/w) was used as a model formulation. The intra-granular distribution of PVP was evaluated by means of hyperspectral coherent anti-Stokes Raman scattering (CARS) microscopy. For the evaluated formulation, no PVP rich zones were detected when applying a lateral spatial resolution of 0.5 μm, indicating that PVP is homogenously distributed within the granules.
AB - According to the quality by design principle processes may not remain black-boxes and full process understanding is required. The granule size distribution of granules produced via twin screw granulation is often found to be bimodal. The aim of this study was to gain a better understanding of binder distribution within granules produced via twin screw granulation in order to investigate if an inhomogeneous spread of binder is causing this bimodal size distribution. Theophylline-lactose-polyvinylpyrrolidone K30 (PVP) (30-67.5-2.5%, w/w) was used as a model formulation. The intra-granular distribution of PVP was evaluated by means of hyperspectral coherent anti-Stokes Raman scattering (CARS) microscopy. For the evaluated formulation, no PVP rich zones were detected when applying a lateral spatial resolution of 0.5 μm, indicating that PVP is homogenously distributed within the granules.
U2 - 10.1016/j.ijpharm.2013.12.008
DO - 10.1016/j.ijpharm.2013.12.008
M3 - Journal article
C2 - 24361911
VL - 462
SP - 8
EP - 10
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -
ID: 104835082