Dissolution of pain-relief drugs: Does beverage choice matter?
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Dissolution of pain-relief drugs : Does beverage choice matter? / Huang, Shouyuan; Salim, Malinda; Barber, Bryce W.; Pham, Anna C.; McDowell, Arlene; Boyd, Ben J.
In: Journal of Drug Delivery Science and Technology, Vol. 91, 105247, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dissolution of pain-relief drugs
T2 - Does beverage choice matter?
AU - Huang, Shouyuan
AU - Salim, Malinda
AU - Barber, Bryce W.
AU - Pham, Anna C.
AU - McDowell, Arlene
AU - Boyd, Ben J.
N1 - Publisher Copyright: © 2023 The Authors
PY - 2024
Y1 - 2024
N2 - Oral administration continues to be the most common route for drug delivery with the majority of approved medicines being tablets and capsule dosage forms. Standardised pharmacopeial media are typically used to test tablet dissolution in vitro, however patients use non-standard beverages to take with their medicines. Information about the dissolution of drugs in beverages consumed by patients has not been reported in the literature. Our aim was to investigate if the choice of beverage influences the dissolution of common pain relief tablets. The prevalence and type of alternative beverages used by patients to take their tablets was investigated in an online survey. The rate of dissolution of the common pain relief tablets, aspirin and acetaminophen, was measured in 15 different dissolution media including pharmacopeial dissolution media, simulated gastrointestinal fluids, and the common alternative beverages used by patients to take their tablets (including water, tea, coffee, soft drink and beer). The concentration of drug dissolved in each beverage over time was determined using either UV–vis spectroscopy or HPLC. The rate of dissolution of aspirin and acetaminophen tablets was in some cases significantly affected by the composition of the dissolution media. Factors such as mineral content, carbonation, and pH contributed to differences in the rate of dissolution for both aspirin and acetaminophen. The rate of dissolution of aspirin was significantly lower in some beverages compared to pharmacopeial media. When translated to the in vivo setting, these differences have the potential to alter the pharmacokinetics and bioavailability of orally administered medicines and so their efficacy.
AB - Oral administration continues to be the most common route for drug delivery with the majority of approved medicines being tablets and capsule dosage forms. Standardised pharmacopeial media are typically used to test tablet dissolution in vitro, however patients use non-standard beverages to take with their medicines. Information about the dissolution of drugs in beverages consumed by patients has not been reported in the literature. Our aim was to investigate if the choice of beverage influences the dissolution of common pain relief tablets. The prevalence and type of alternative beverages used by patients to take their tablets was investigated in an online survey. The rate of dissolution of the common pain relief tablets, aspirin and acetaminophen, was measured in 15 different dissolution media including pharmacopeial dissolution media, simulated gastrointestinal fluids, and the common alternative beverages used by patients to take their tablets (including water, tea, coffee, soft drink and beer). The concentration of drug dissolved in each beverage over time was determined using either UV–vis spectroscopy or HPLC. The rate of dissolution of aspirin and acetaminophen tablets was in some cases significantly affected by the composition of the dissolution media. Factors such as mineral content, carbonation, and pH contributed to differences in the rate of dissolution for both aspirin and acetaminophen. The rate of dissolution of aspirin was significantly lower in some beverages compared to pharmacopeial media. When translated to the in vivo setting, these differences have the potential to alter the pharmacokinetics and bioavailability of orally administered medicines and so their efficacy.
KW - Acetaminophen
KW - Aspirin
KW - Beverage
KW - Dissolution
KW - Similarity test
U2 - 10.1016/j.jddst.2023.105247
DO - 10.1016/j.jddst.2023.105247
M3 - Journal article
AN - SCOPUS:85179921051
VL - 91
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
SN - 1773-2247
M1 - 105247
ER -
ID: 378753925