Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems

Research output: Contribution to journalJournal articleResearchpeer-review

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Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems. / Kheawfu, Kantaporn; Pikulkaew, Surachai; Rades, Thomas; Müllertz, Anette; Okonogi, Siriporn.

In: Journal of Drug Delivery Science and Technology, Vol. 46, 2018, p. 330-338.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kheawfu, K, Pikulkaew, S, Rades, T, Müllertz, A & Okonogi, S 2018, 'Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems', Journal of Drug Delivery Science and Technology, vol. 46, pp. 330-338. https://doi.org/10.1016/j.jddst.2018.05.028

APA

Kheawfu, K., Pikulkaew, S., Rades, T., Müllertz, A., & Okonogi, S. (2018). Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems. Journal of Drug Delivery Science and Technology, 46, 330-338. https://doi.org/10.1016/j.jddst.2018.05.028

Vancouver

Kheawfu K, Pikulkaew S, Rades T, Müllertz A, Okonogi S. Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems. Journal of Drug Delivery Science and Technology. 2018;46:330-338. https://doi.org/10.1016/j.jddst.2018.05.028

Author

Kheawfu, Kantaporn ; Pikulkaew, Surachai ; Rades, Thomas ; Müllertz, Anette ; Okonogi, Siriporn. / Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems. In: Journal of Drug Delivery Science and Technology. 2018 ; Vol. 46. pp. 330-338.

Bibtex

@article{10831398ef06494a97beb93fcd6bdbce,
title = "Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems",
abstract = "This study was carried out to develop clove oil nanoformulations with reduced or no ethanol to increase the aqueous miscibility of clove oil for use in fish anesthesia. The droplets of clove oil nanoemulsion (C-NE) and self-microemulsifying drug delivery systems (C-SMEDDS) were characterized using photon correlation spectroscopy and transmission electron microscope. The droplet size of C-NE containing 10–20{\%} clove oil and 5–15{\%} polysorbate 20 was 23–133 nm, whereas that of C-SMEDDS composed of 10{\%} clove oil and 90{\%} polysorbate 20 or 10{\%} clove oil and 60{\%} polysorbate 20 and 30{\%} ethanol or isopropanol was 11–44 nm. The droplets were roughly spherical. After stored for 90 days, at 4 °C, most C-NE and C-SMEDDS showed no change in appearance and droplet size. Low degradation rate of eugenol, a major compound of clove oil, was found at this temperature. Anesthesia induction times of C-NE composed of 10–20{\%} clove oil and 5–10{\%} polysorbate 20, and C-SMEDDS composed of 60{\%} polysorbate 20 and 30{\%} co-solvent in goldfish were 4.0 ± 0.6 min and 3.8 ± 0.9 min, respectively, significantly shorter than that of clove oil ethanolic solution (5.0 ± 0.9 min), but there was no significant difference in the recovery time.",
keywords = "Carassius auratus, Clove oil, Eugenol, Fish anesthesia, Nanoemulsions, SMEDDS",
author = "Kantaporn Kheawfu and Surachai Pikulkaew and Thomas Rades and Anette M{\"u}llertz and Siriporn Okonogi",
year = "2018",
doi = "10.1016/j.jddst.2018.05.028",
language = "English",
volume = "46",
pages = "330--338",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems

AU - Kheawfu, Kantaporn

AU - Pikulkaew, Surachai

AU - Rades, Thomas

AU - Müllertz, Anette

AU - Okonogi, Siriporn

PY - 2018

Y1 - 2018

N2 - This study was carried out to develop clove oil nanoformulations with reduced or no ethanol to increase the aqueous miscibility of clove oil for use in fish anesthesia. The droplets of clove oil nanoemulsion (C-NE) and self-microemulsifying drug delivery systems (C-SMEDDS) were characterized using photon correlation spectroscopy and transmission electron microscope. The droplet size of C-NE containing 10–20% clove oil and 5–15% polysorbate 20 was 23–133 nm, whereas that of C-SMEDDS composed of 10% clove oil and 90% polysorbate 20 or 10% clove oil and 60% polysorbate 20 and 30% ethanol or isopropanol was 11–44 nm. The droplets were roughly spherical. After stored for 90 days, at 4 °C, most C-NE and C-SMEDDS showed no change in appearance and droplet size. Low degradation rate of eugenol, a major compound of clove oil, was found at this temperature. Anesthesia induction times of C-NE composed of 10–20% clove oil and 5–10% polysorbate 20, and C-SMEDDS composed of 60% polysorbate 20 and 30% co-solvent in goldfish were 4.0 ± 0.6 min and 3.8 ± 0.9 min, respectively, significantly shorter than that of clove oil ethanolic solution (5.0 ± 0.9 min), but there was no significant difference in the recovery time.

AB - This study was carried out to develop clove oil nanoformulations with reduced or no ethanol to increase the aqueous miscibility of clove oil for use in fish anesthesia. The droplets of clove oil nanoemulsion (C-NE) and self-microemulsifying drug delivery systems (C-SMEDDS) were characterized using photon correlation spectroscopy and transmission electron microscope. The droplet size of C-NE containing 10–20% clove oil and 5–15% polysorbate 20 was 23–133 nm, whereas that of C-SMEDDS composed of 10% clove oil and 90% polysorbate 20 or 10% clove oil and 60% polysorbate 20 and 30% ethanol or isopropanol was 11–44 nm. The droplets were roughly spherical. After stored for 90 days, at 4 °C, most C-NE and C-SMEDDS showed no change in appearance and droplet size. Low degradation rate of eugenol, a major compound of clove oil, was found at this temperature. Anesthesia induction times of C-NE composed of 10–20% clove oil and 5–10% polysorbate 20, and C-SMEDDS composed of 60% polysorbate 20 and 30% co-solvent in goldfish were 4.0 ± 0.6 min and 3.8 ± 0.9 min, respectively, significantly shorter than that of clove oil ethanolic solution (5.0 ± 0.9 min), but there was no significant difference in the recovery time.

KW - Carassius auratus

KW - Clove oil

KW - Eugenol

KW - Fish anesthesia

KW - Nanoemulsions

KW - SMEDDS

U2 - 10.1016/j.jddst.2018.05.028

DO - 10.1016/j.jddst.2018.05.028

M3 - Journal article

AN - SCOPUS:85047620041

VL - 46

SP - 330

EP - 338

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

ER -

ID: 220851209