Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems
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Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems. / Kheawfu, Kantaporn; Pikulkaew, Surachai; Rades, Thomas; Müllertz, Anette; Okonogi, Siriporn.
In: Journal of Drug Delivery Science and Technology, Vol. 46, 2018, p. 330-338.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems
AU - Kheawfu, Kantaporn
AU - Pikulkaew, Surachai
AU - Rades, Thomas
AU - Müllertz, Anette
AU - Okonogi, Siriporn
PY - 2018
Y1 - 2018
N2 - This study was carried out to develop clove oil nanoformulations with reduced or no ethanol to increase the aqueous miscibility of clove oil for use in fish anesthesia. The droplets of clove oil nanoemulsion (C-NE) and self-microemulsifying drug delivery systems (C-SMEDDS) were characterized using photon correlation spectroscopy and transmission electron microscope. The droplet size of C-NE containing 10–20% clove oil and 5–15% polysorbate 20 was 23–133 nm, whereas that of C-SMEDDS composed of 10% clove oil and 90% polysorbate 20 or 10% clove oil and 60% polysorbate 20 and 30% ethanol or isopropanol was 11–44 nm. The droplets were roughly spherical. After stored for 90 days, at 4 °C, most C-NE and C-SMEDDS showed no change in appearance and droplet size. Low degradation rate of eugenol, a major compound of clove oil, was found at this temperature. Anesthesia induction times of C-NE composed of 10–20% clove oil and 5–10% polysorbate 20, and C-SMEDDS composed of 60% polysorbate 20 and 30% co-solvent in goldfish were 4.0 ± 0.6 min and 3.8 ± 0.9 min, respectively, significantly shorter than that of clove oil ethanolic solution (5.0 ± 0.9 min), but there was no significant difference in the recovery time.
AB - This study was carried out to develop clove oil nanoformulations with reduced or no ethanol to increase the aqueous miscibility of clove oil for use in fish anesthesia. The droplets of clove oil nanoemulsion (C-NE) and self-microemulsifying drug delivery systems (C-SMEDDS) were characterized using photon correlation spectroscopy and transmission electron microscope. The droplet size of C-NE containing 10–20% clove oil and 5–15% polysorbate 20 was 23–133 nm, whereas that of C-SMEDDS composed of 10% clove oil and 90% polysorbate 20 or 10% clove oil and 60% polysorbate 20 and 30% ethanol or isopropanol was 11–44 nm. The droplets were roughly spherical. After stored for 90 days, at 4 °C, most C-NE and C-SMEDDS showed no change in appearance and droplet size. Low degradation rate of eugenol, a major compound of clove oil, was found at this temperature. Anesthesia induction times of C-NE composed of 10–20% clove oil and 5–10% polysorbate 20, and C-SMEDDS composed of 60% polysorbate 20 and 30% co-solvent in goldfish were 4.0 ± 0.6 min and 3.8 ± 0.9 min, respectively, significantly shorter than that of clove oil ethanolic solution (5.0 ± 0.9 min), but there was no significant difference in the recovery time.
KW - Carassius auratus
KW - Clove oil
KW - Eugenol
KW - Fish anesthesia
KW - Nanoemulsions
KW - SMEDDS
U2 - 10.1016/j.jddst.2018.05.028
DO - 10.1016/j.jddst.2018.05.028
M3 - Journal article
AN - SCOPUS:85047620041
VL - 46
SP - 330
EP - 338
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
SN - 1773-2247
ER -
ID: 220851209