Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. / Kojarunchitt, Thunjiradasiree; Hook, Sarah; Rizwan, Shakila; Rades, Thomas; Baldursdottir, Stefania.

In: International Journal of Pharmaceutics, Vol. 408, No. 1-2, 2011, p. 20-26.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kojarunchitt, T, Hook, S, Rizwan, S, Rades, T & Baldursdottir, S 2011, 'Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes', International Journal of Pharmaceutics, vol. 408, no. 1-2, pp. 20-26. https://doi.org/10.1016/j.ijpharm.2011.01.037

APA

Kojarunchitt, T., Hook, S., Rizwan, S., Rades, T., & Baldursdottir, S. (2011). Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. International Journal of Pharmaceutics, 408(1-2), 20-26. https://doi.org/10.1016/j.ijpharm.2011.01.037

Vancouver

Kojarunchitt T, Hook S, Rizwan S, Rades T, Baldursdottir S. Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. International Journal of Pharmaceutics. 2011;408(1-2):20-26. https://doi.org/10.1016/j.ijpharm.2011.01.037

Author

Kojarunchitt, Thunjiradasiree ; Hook, Sarah ; Rizwan, Shakila ; Rades, Thomas ; Baldursdottir, Stefania. / Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. In: International Journal of Pharmaceutics. 2011 ; Vol. 408, No. 1-2. pp. 20-26.

Bibtex

@article{5c597c0b7156414787191bb1183e5da2,

title = "Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes",

abstract = "The purpose of this study is to develop a thermoresponsive sustained release delivery system combining phytantriol cubosomes and poloxamer 407 (P407). P407 undergoes thermoreversible gelation, where it exists as a free-flowing liquid at low temperature and gels upon heating. However, this polymer has the major draw back of fast erosion in aqueous environments which needs to be addressed. Three different concentrations of P407 (12%, 15% and 17% (w/v)) were formulated with various additives (methyl cellulose (MC), dextran, carrageenan and Pluronic-R (25R4)). The rheological characteristics and in vitro stability were investigated. The sol-gel transition temperature of P407 was lowered in the presence of the phytantriol cubosomes. The addition of MC and dextran did not affect the sol-gel transition temperature whereas 25R4 increased the gelation temperature. No transition was observed for the carrageenan formulations. The presence of 25R4 allowed the development of formulations that were free flowing liquid at working temperature (22 °C), gelled at body temperature (37 °C) and had improved stability in an aqueous environment. Both rheological and in vitro stability studies suggested that cubosome-loaded 17% (w/v) P407 with 25R4 in 1:1 molar ratio may have a potential as sustained release delivery system.",

keywords = "Delayed-Action Preparations, Drug Carriers, Drug Stability, Excipients, Gels, Micelles, Phase Transition, Poloxamer, Rheology, Technology, Pharmaceutical, Temperature, Vaccines, Viscosity",

author = "Thunjiradasiree Kojarunchitt and Sarah Hook and Shakila Rizwan and Thomas Rades and Stefania Baldursdottir",

year = "2011",

doi = "10.1016/j.ijpharm.2011.01.037",

language = "English",

volume = "408",

pages = "20--26",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier",

number = "1-2",

}

RIS

TY - JOUR

T1 - Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes

AU - Kojarunchitt, Thunjiradasiree

AU - Hook, Sarah

AU - Rizwan, Shakila

AU - Rades, Thomas

AU - Baldursdottir, Stefania

PY - 2011

Y1 - 2011

N2 - The purpose of this study is to develop a thermoresponsive sustained release delivery system combining phytantriol cubosomes and poloxamer 407 (P407). P407 undergoes thermoreversible gelation, where it exists as a free-flowing liquid at low temperature and gels upon heating. However, this polymer has the major draw back of fast erosion in aqueous environments which needs to be addressed. Three different concentrations of P407 (12%, 15% and 17% (w/v)) were formulated with various additives (methyl cellulose (MC), dextran, carrageenan and Pluronic-R (25R4)). The rheological characteristics and in vitro stability were investigated. The sol-gel transition temperature of P407 was lowered in the presence of the phytantriol cubosomes. The addition of MC and dextran did not affect the sol-gel transition temperature whereas 25R4 increased the gelation temperature. No transition was observed for the carrageenan formulations. The presence of 25R4 allowed the development of formulations that were free flowing liquid at working temperature (22 °C), gelled at body temperature (37 °C) and had improved stability in an aqueous environment. Both rheological and in vitro stability studies suggested that cubosome-loaded 17% (w/v) P407 with 25R4 in 1:1 molar ratio may have a potential as sustained release delivery system.

AB - The purpose of this study is to develop a thermoresponsive sustained release delivery system combining phytantriol cubosomes and poloxamer 407 (P407). P407 undergoes thermoreversible gelation, where it exists as a free-flowing liquid at low temperature and gels upon heating. However, this polymer has the major draw back of fast erosion in aqueous environments which needs to be addressed. Three different concentrations of P407 (12%, 15% and 17% (w/v)) were formulated with various additives (methyl cellulose (MC), dextran, carrageenan and Pluronic-R (25R4)). The rheological characteristics and in vitro stability were investigated. The sol-gel transition temperature of P407 was lowered in the presence of the phytantriol cubosomes. The addition of MC and dextran did not affect the sol-gel transition temperature whereas 25R4 increased the gelation temperature. No transition was observed for the carrageenan formulations. The presence of 25R4 allowed the development of formulations that were free flowing liquid at working temperature (22 °C), gelled at body temperature (37 °C) and had improved stability in an aqueous environment. Both rheological and in vitro stability studies suggested that cubosome-loaded 17% (w/v) P407 with 25R4 in 1:1 molar ratio may have a potential as sustained release delivery system.

KW - Delayed-Action Preparations

KW - Drug Carriers

KW - Drug Stability

KW - Excipients

KW - Gels

KW - Micelles

KW - Phase Transition

KW - Poloxamer

KW - Rheology

KW - Technology, Pharmaceutical

KW - Temperature

KW - Vaccines

KW - Viscosity

U2 - 10.1016/j.ijpharm.2011.01.037

DO - 10.1016/j.ijpharm.2011.01.037

M3 - Journal article

C2 - 21272624

VL - 408

SP - 20

EP - 26

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 33229929

Department of Pharmacy