Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress. / Di, Rong; Grohganz, Holger; Rades, Thomas.

In: Pharmaceutics, Vol. 16, 67, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Di, R, Grohganz, H & Rades, T 2024, 'Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress', Pharmaceutics, vol. 16, 67. https://doi.org/10.3390/pharmaceutics16010067

APA

Di, R., Grohganz, H., & Rades, T. (2024). Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress. Pharmaceutics, 16, [67]. https://doi.org/10.3390/pharmaceutics16010067

Vancouver

Di R, Grohganz H, Rades T. Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress. Pharmaceutics. 2024;16. 67. https://doi.org/10.3390/pharmaceutics16010067

Author

Di, Rong ; Grohganz, Holger ; Rades, Thomas. / Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress. In: Pharmaceutics. 2024 ; Vol. 16.

Bibtex

@article{8a068d6b5e794512b21c6c52998f4070,
title = "Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress",
abstract = "Using co-amorphous systems (CAMS) has shown promise in addressing the challenges associated with poorly water-soluble drugs. Quench-cooling is a commonly used CAMS preparation method, often followed by grinding or milling to achieve a fine powder that is suitable for subsequent characterization or further down-stream manufacturing. However, the impact of mechanical stress applied to CAMS has received little attention. In this study, the influence of mechanical stress on indomethacin—paracetamol CAMS was investigated. The investigation involved thermal analysis and solid-state characterization across various CAMS mixing ratios and levels of mechanical stress. The study revealed a negative effect of mechanical stress on stability, particularly on the excess components in CAMS. Higher levels of mechanical stress were observed to induce phase separation or recrystallization. Notably, samples at the optimal mixing ratio demonstrated greater resistance to the destabilization caused by mechanical stress. These results showed the significance of careful consideration of processing methods during formulation and the significance of optimizing mixing ratios in CAMS.",
author = "Rong Di and Holger Grohganz and Thomas Rades",
year = "2024",
doi = "10.3390/pharmaceutics16010067",
language = "English",
volume = "16",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",

}

RIS

TY - JOUR

T1 - Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress

AU - Di, Rong

AU - Grohganz, Holger

AU - Rades, Thomas

PY - 2024

Y1 - 2024

N2 - Using co-amorphous systems (CAMS) has shown promise in addressing the challenges associated with poorly water-soluble drugs. Quench-cooling is a commonly used CAMS preparation method, often followed by grinding or milling to achieve a fine powder that is suitable for subsequent characterization or further down-stream manufacturing. However, the impact of mechanical stress applied to CAMS has received little attention. In this study, the influence of mechanical stress on indomethacin—paracetamol CAMS was investigated. The investigation involved thermal analysis and solid-state characterization across various CAMS mixing ratios and levels of mechanical stress. The study revealed a negative effect of mechanical stress on stability, particularly on the excess components in CAMS. Higher levels of mechanical stress were observed to induce phase separation or recrystallization. Notably, samples at the optimal mixing ratio demonstrated greater resistance to the destabilization caused by mechanical stress. These results showed the significance of careful consideration of processing methods during formulation and the significance of optimizing mixing ratios in CAMS.

AB - Using co-amorphous systems (CAMS) has shown promise in addressing the challenges associated with poorly water-soluble drugs. Quench-cooling is a commonly used CAMS preparation method, often followed by grinding or milling to achieve a fine powder that is suitable for subsequent characterization or further down-stream manufacturing. However, the impact of mechanical stress applied to CAMS has received little attention. In this study, the influence of mechanical stress on indomethacin—paracetamol CAMS was investigated. The investigation involved thermal analysis and solid-state characterization across various CAMS mixing ratios and levels of mechanical stress. The study revealed a negative effect of mechanical stress on stability, particularly on the excess components in CAMS. Higher levels of mechanical stress were observed to induce phase separation or recrystallization. Notably, samples at the optimal mixing ratio demonstrated greater resistance to the destabilization caused by mechanical stress. These results showed the significance of careful consideration of processing methods during formulation and the significance of optimizing mixing ratios in CAMS.

U2 - 10.3390/pharmaceutics16010067

DO - 10.3390/pharmaceutics16010067

M3 - Journal article

C2 - 38258078

VL - 16

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

M1 - 67

ER -

ID: 382370288