Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying

Research output: Contribution to journalReviewResearchpeer-review

Currently, most of the approved protein and peptide-based medicines are delivered via conventional parenteral injection (intramuscular, subcutaneous or intravenous). A frequent dosing regimen is often necessary because of their short plasma half-lives, causing poor patient compliance (e.g. pain, abscess, etc.), side effects owing to typical peak-valley plasma concentration time profiles, and increased costs. Among many sustained-release formulations poly lactic-co-glycolic acid (PLGA)-based depot microparticle systems may represent one of the most promising approaches to provide protein and peptide drugs with a steady pharmacokinetic/pharmacodynamic profile maintained for a long period. However, the development of PLGA-based microparticle systems is still impeded by lack of easy, fast, effective manufacturing technologies. The aim of this paper is to review recent advances in spray drying, a one-step, continuous microencapsulation process, for manufacturing of PLGA-based depot microparticle systems with a focus on the recent efforts on understanding of the role of nozzle design in the microencapsulation of proteins/peptides, and the effect of critical solvent properties and process parameters on the critical quality attributes of the spray-dried microparticles.

Original languageEnglish
JournalInternational Journal of Pharmaceutics
Issue number1-2
Pages (from-to)82-95
Number of pages14
Publication statusPublished - 10 Feb 2016

    Research areas

  • Animals, Biopharmaceutics, Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Delivery Systems, Drug Design, Humans, Lactic Acid, Polyglycolic Acid, Journal Article, Research Support, Non-U.S. Gov't, Review

ID: 169413816