Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia

Research output: Contribution to journalJournal articlepeer-review

Standard

Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia. / Kheawfu; Pikulkaew, ; Rades, Thomas; Mullertz, Anette ; Jørgensen, Louise von Gersdorff; Okonogi.

In: Journal of Drug Delivery Science and Technology, Vol. 61, 102241, 2021.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kheawfu, Pikulkaew, , Rades, T, Mullertz, A, Jørgensen, LVG & Okonogi 2021, 'Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia', Journal of Drug Delivery Science and Technology, vol. 61, 102241. https://doi.org/10.1016/j.jddst.2020.102241

APA

Kheawfu, Pikulkaew, Rades, T., Mullertz, A., Jørgensen, L. V. G., & Okonogi (2021). Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia. Journal of Drug Delivery Science and Technology, 61, [102241]. https://doi.org/10.1016/j.jddst.2020.102241

Vancouver

Kheawfu, Pikulkaew , Rades T, Mullertz A, Jørgensen LVG, Okonogi. Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia. Journal of Drug Delivery Science and Technology. 2021;61. 102241. https://doi.org/10.1016/j.jddst.2020.102241

Author

Kheawfu ; Pikulkaew, ; Rades, Thomas ; Mullertz, Anette ; Jørgensen, Louise von Gersdorff ; Okonogi. / Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia. In: Journal of Drug Delivery Science and Technology. 2021 ; Vol. 61.

Bibtex

@article{0e7378441c81431d8722768298df9a46,
title = "Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia",
abstract = "Self-nanoemulsifying drug delivery system (SNEDDS) is an efficient system for delivering water-insoluble compounds. The aim of this study was to develop SNEDDS containing clove oil (C-SNEDDS) to increase clove oil aqueous miscibility and for fish anesthesia. C-SNEDDS was prepared using different lipids and surfactants. An axial extended design was used to select suitable components. The effects of components on dispersing time, droplet size, and size distribution of the dispersed C-SNEDDS were investigated. D-optimal experimental design, multiple linear regression, and partial least squares regression were employed to optimize the formulation variables, X1 (clove oil), X2 (lipid), and X3 (surfactant) for preparing high clove oil loading C-SNEDDS. Clove oil and surfactant showed a significant effect on the droplet size. Spherical droplets could be observed under cryogenic transmission electron microscopy from the small-size dispersed C-SNEDDS. C-SNEDDS using 1:1 ratio of Captex-Capmul and Kolliphor EL showed high clove oil loading of 35–36%. The droplet size demonstrated a high impact on the induction time to anesthesia but not on the recovery time. The dispersed C-SNEDDS with an average droplet size of 58.2 ± 0.9 nm significantly showed a fast induction time of approximately 2.5 min, 2-fold significantly faster than MS-222.",
author = "Kheawfu and Pikulkaew and Thomas Rades and Anette Mullertz and J{\o}rgensen, {Louise von Gersdorff} and Okonogi",
year = "2021",
doi = "10.1016/j.jddst.2020.102241",
language = "English",
volume = "61",
journal = "Journal of Drug Delivery Science and Technology",
issn = "1773-2247",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia

AU - Kheawfu, null

AU - Pikulkaew, null

AU - Rades, Thomas

AU - Mullertz, Anette

AU - Jørgensen, Louise von Gersdorff

AU - Okonogi, null

PY - 2021

Y1 - 2021

N2 - Self-nanoemulsifying drug delivery system (SNEDDS) is an efficient system for delivering water-insoluble compounds. The aim of this study was to develop SNEDDS containing clove oil (C-SNEDDS) to increase clove oil aqueous miscibility and for fish anesthesia. C-SNEDDS was prepared using different lipids and surfactants. An axial extended design was used to select suitable components. The effects of components on dispersing time, droplet size, and size distribution of the dispersed C-SNEDDS were investigated. D-optimal experimental design, multiple linear regression, and partial least squares regression were employed to optimize the formulation variables, X1 (clove oil), X2 (lipid), and X3 (surfactant) for preparing high clove oil loading C-SNEDDS. Clove oil and surfactant showed a significant effect on the droplet size. Spherical droplets could be observed under cryogenic transmission electron microscopy from the small-size dispersed C-SNEDDS. C-SNEDDS using 1:1 ratio of Captex-Capmul and Kolliphor EL showed high clove oil loading of 35–36%. The droplet size demonstrated a high impact on the induction time to anesthesia but not on the recovery time. The dispersed C-SNEDDS with an average droplet size of 58.2 ± 0.9 nm significantly showed a fast induction time of approximately 2.5 min, 2-fold significantly faster than MS-222.

AB - Self-nanoemulsifying drug delivery system (SNEDDS) is an efficient system for delivering water-insoluble compounds. The aim of this study was to develop SNEDDS containing clove oil (C-SNEDDS) to increase clove oil aqueous miscibility and for fish anesthesia. C-SNEDDS was prepared using different lipids and surfactants. An axial extended design was used to select suitable components. The effects of components on dispersing time, droplet size, and size distribution of the dispersed C-SNEDDS were investigated. D-optimal experimental design, multiple linear regression, and partial least squares regression were employed to optimize the formulation variables, X1 (clove oil), X2 (lipid), and X3 (surfactant) for preparing high clove oil loading C-SNEDDS. Clove oil and surfactant showed a significant effect on the droplet size. Spherical droplets could be observed under cryogenic transmission electron microscopy from the small-size dispersed C-SNEDDS. C-SNEDDS using 1:1 ratio of Captex-Capmul and Kolliphor EL showed high clove oil loading of 35–36%. The droplet size demonstrated a high impact on the induction time to anesthesia but not on the recovery time. The dispersed C-SNEDDS with an average droplet size of 58.2 ± 0.9 nm significantly showed a fast induction time of approximately 2.5 min, 2-fold significantly faster than MS-222.

U2 - 10.1016/j.jddst.2020.102241

DO - 10.1016/j.jddst.2020.102241

M3 - Journal article

VL - 61

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

M1 - 102241

ER -

ID: 254524072