Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing. / Öblom, Heidi; Cornett, Claus; Bøtker, Johan; Frokjaer, Sven; Hansen, Harald; Rades, Thomas; Rantanen, Jukka; Genina, Natalja.

In: International Journal of Pharmaceutics, Vol. 589, 119866, 2020, p. 1-11.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Öblom, H, Cornett, C, Bøtker, J, Frokjaer, S, Hansen, H, Rades, T, Rantanen, J & Genina, N 2020, 'Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing', International Journal of Pharmaceutics, vol. 589, 119866, pp. 1-11. https://doi.org/10.1016/j.ijpharm.2020.119866

APA

Öblom, H., Cornett, C., Bøtker, J., Frokjaer, S., Hansen, H., Rades, T., ... Genina, N. (2020). Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing. International Journal of Pharmaceutics, 589, 1-11. [119866]. https://doi.org/10.1016/j.ijpharm.2020.119866

Vancouver

Öblom H, Cornett C, Bøtker J, Frokjaer S, Hansen H, Rades T et al. Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing. International Journal of Pharmaceutics. 2020;589:1-11. 119866. https://doi.org/10.1016/j.ijpharm.2020.119866

Author

Öblom, Heidi ; Cornett, Claus ; Bøtker, Johan ; Frokjaer, Sven ; Hansen, Harald ; Rades, Thomas ; Rantanen, Jukka ; Genina, Natalja. / Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing. In: International Journal of Pharmaceutics. 2020 ; Vol. 589. pp. 1-11.

Bibtex

@article{696b14e12f264c228d1efedddca9327c,
title = "Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing",
abstract = "Medical cannabis has shown to be effective in various diseases that have not successfully been treated with other marketed drug products. However, the dose of cannabis is highly individual and additionally, medical cannabis is prone to misuse. To combat these challenges, the concept of data-enriched edible pharmaceuticals (DEEP) is introduced. Quick Response (QR) code patterns containing lipophilic cannabinoids, i.e., cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), were printed using a desktop inkjet printer. This allows for simultaneously printing an individual dose and encapsulating information relevant to the end-users and other stakeholders in a single dosage unit, which is readable by a standard smartphone. Different doses of CBD and THC were incorporated in the DEEP by printing various (1-10) layers of the cannabinoid-containing ink on porous substrates, i.e., solid foams, prepared by solvent casting and subsequent freeze-drying. The printed DEEP were still readable after 8 weeks of storage in dry and cold conditions. This approach of ‘in-drug labeling’ instead of ‘drug package labeling’ provides a new possibility for developing a more efficient supply chain of pharmaceuticals and safer medication schemes by increasing the traceability of drug products at a single dosage unit level.",
keywords = "cannabinoids, data, inkjet printing, misuse, personalized medicine, traceability, QR code",
author = "Heidi {\"O}blom and Claus Cornett and Johan B{\o}tker and Sven Frokjaer and Harald Hansen and Thomas Rades and Jukka Rantanen and Natalja Genina",
year = "2020",
doi = "10.1016/j.ijpharm.2020.119866",
language = "Dansk",
volume = "589",
pages = "1--11",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Data-enriched edible pharmaceuticals (DEEP) of medical cannabis by inkjet printing

AU - Öblom, Heidi

AU - Cornett, Claus

AU - Bøtker, Johan

AU - Frokjaer, Sven

AU - Hansen, Harald

AU - Rades, Thomas

AU - Rantanen, Jukka

AU - Genina, Natalja

PY - 2020

Y1 - 2020

N2 - Medical cannabis has shown to be effective in various diseases that have not successfully been treated with other marketed drug products. However, the dose of cannabis is highly individual and additionally, medical cannabis is prone to misuse. To combat these challenges, the concept of data-enriched edible pharmaceuticals (DEEP) is introduced. Quick Response (QR) code patterns containing lipophilic cannabinoids, i.e., cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), were printed using a desktop inkjet printer. This allows for simultaneously printing an individual dose and encapsulating information relevant to the end-users and other stakeholders in a single dosage unit, which is readable by a standard smartphone. Different doses of CBD and THC were incorporated in the DEEP by printing various (1-10) layers of the cannabinoid-containing ink on porous substrates, i.e., solid foams, prepared by solvent casting and subsequent freeze-drying. The printed DEEP were still readable after 8 weeks of storage in dry and cold conditions. This approach of ‘in-drug labeling’ instead of ‘drug package labeling’ provides a new possibility for developing a more efficient supply chain of pharmaceuticals and safer medication schemes by increasing the traceability of drug products at a single dosage unit level.

AB - Medical cannabis has shown to be effective in various diseases that have not successfully been treated with other marketed drug products. However, the dose of cannabis is highly individual and additionally, medical cannabis is prone to misuse. To combat these challenges, the concept of data-enriched edible pharmaceuticals (DEEP) is introduced. Quick Response (QR) code patterns containing lipophilic cannabinoids, i.e., cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), were printed using a desktop inkjet printer. This allows for simultaneously printing an individual dose and encapsulating information relevant to the end-users and other stakeholders in a single dosage unit, which is readable by a standard smartphone. Different doses of CBD and THC were incorporated in the DEEP by printing various (1-10) layers of the cannabinoid-containing ink on porous substrates, i.e., solid foams, prepared by solvent casting and subsequent freeze-drying. The printed DEEP were still readable after 8 weeks of storage in dry and cold conditions. This approach of ‘in-drug labeling’ instead of ‘drug package labeling’ provides a new possibility for developing a more efficient supply chain of pharmaceuticals and safer medication schemes by increasing the traceability of drug products at a single dosage unit level.

KW - cannabinoids

KW - data

KW - inkjet printing

KW - misuse

KW - personalized medicine

KW - traceability

KW - QR code

U2 - 10.1016/j.ijpharm.2020.119866

DO - 10.1016/j.ijpharm.2020.119866

M3 - Tidsskriftartikel

C2 - 32919002

VL - 589

SP - 1

EP - 11

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

M1 - 119866

ER -

ID: 248289043