Crystallization of Piroxicam Solid Forms and the Effects of Additives

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Guangpu Liu, Thomas B. Hansen, Haiyan Qu, Mingshi Yang, Jari P. Pajander, Jukka Rantanen, Lars P. Christensen

The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.

Original languageEnglish
JournalChemical Engineering and Technology
Volume37
Issue number8
Pages (from-to)1297-1304
Number of pages8
ISSN0930-7516
DOIs
Publication statusPublished - 2014

    Research areas

  • Crystallization, Effect of additives, Monohydrate, Pharmaceutical products, Polymorphism, Relative thermodynamic stability

ID: 221827548