Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations. / Wickström, Henrika; Nyman, Johan O; Indola, Mathias; Sundelin, Heidi; Kronberg, Leif; Preis, Maren; Rantanen, Jukka; Sandler, Niklas.

In: A A P S PharmSciTech, Vol. 18, No. 2, 2017, p. 293-302.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Wickström, H, Nyman, JO, Indola, M, Sundelin, H, Kronberg, L, Preis, M, Rantanen, J & Sandler, N 2017, 'Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations', A A P S PharmSciTech, vol. 18, no. 2, pp. 293-302. https://doi.org/10.1208/s12249-016-0620-1

APA

Wickström, H., Nyman, J. O., Indola, M., Sundelin, H., Kronberg, L., Preis, M., ... Sandler, N. (2017). Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations. A A P S PharmSciTech, 18(2), 293-302. https://doi.org/10.1208/s12249-016-0620-1

Vancouver

Wickström H, Nyman JO, Indola M, Sundelin H, Kronberg L, Preis M et al. Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations. A A P S PharmSciTech. 2017;18(2):293-302. https://doi.org/10.1208/s12249-016-0620-1

Author

Wickström, Henrika ; Nyman, Johan O ; Indola, Mathias ; Sundelin, Heidi ; Kronberg, Leif ; Preis, Maren ; Rantanen, Jukka ; Sandler, Niklas. / Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations. In: A A P S PharmSciTech. 2017 ; Vol. 18, No. 2. pp. 293-302.

Bibtex

@article{c953ea2ac89e419aabbfd697d3faa283,
title = "Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations",
abstract = "Printing technologies were recently introduced to the pharmaceutical field for manufacturing of drug delivery systems. Printing allows on demand manufacturing of flexible pharmaceutical doses in a personalized manner, which is critical for a successful and safe treatment of patient populations with specific needs, such as children and the elderly, and patients facing multimorbidity. Printing of pharmaceuticals as technique generates new demands on the quality control procedures. For example, rapid quality control is needed as the printing can be done on demand and at the point of care. This study evaluated the potential use of a handheld colorimetry device for quality control of printed doses of vitamin Bs on edible rice and sugar substrates. The structural features of the substrates with and without ink were also compared. A multicomponent ink formulation with vitamin B1, B2, B3, and B6 was developed. Doses (4 cm(2)) were prepared by applying 1-10 layers of yellow ink onto the white substrates using thermal inkjet technology. The colorimetric method was seen to be viable in detecting doses up to the 5th and 6th printed layers until color saturation of the yellow color parameter (b*) was observed on the substrates. Liquid chromatography mass spectrometry was used as a reference method for the colorimetry measurements plotted against the number of printed layers. It was concluded that colorimetry could be used as a quality control tool for detection of different doses. However, optimization of the color addition needs to be done to avoid color saturation within the planned dose interval.",
author = "Henrika Wickstr{\"o}m and Nyman, {Johan O} and Mathias Indola and Heidi Sundelin and Leif Kronberg and Maren Preis and Jukka Rantanen and Niklas Sandler",
year = "2017",
doi = "10.1208/s12249-016-0620-1",
language = "English",
volume = "18",
pages = "293--302",
journal = "A A P S PharmSciTech",
issn = "1530-9932",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Colorimetry as Quality Control Tool for Individual Inkjet-Printed Pediatric Formulations

AU - Wickström, Henrika

AU - Nyman, Johan O

AU - Indola, Mathias

AU - Sundelin, Heidi

AU - Kronberg, Leif

AU - Preis, Maren

AU - Rantanen, Jukka

AU - Sandler, Niklas

PY - 2017

Y1 - 2017

N2 - Printing technologies were recently introduced to the pharmaceutical field for manufacturing of drug delivery systems. Printing allows on demand manufacturing of flexible pharmaceutical doses in a personalized manner, which is critical for a successful and safe treatment of patient populations with specific needs, such as children and the elderly, and patients facing multimorbidity. Printing of pharmaceuticals as technique generates new demands on the quality control procedures. For example, rapid quality control is needed as the printing can be done on demand and at the point of care. This study evaluated the potential use of a handheld colorimetry device for quality control of printed doses of vitamin Bs on edible rice and sugar substrates. The structural features of the substrates with and without ink were also compared. A multicomponent ink formulation with vitamin B1, B2, B3, and B6 was developed. Doses (4 cm(2)) were prepared by applying 1-10 layers of yellow ink onto the white substrates using thermal inkjet technology. The colorimetric method was seen to be viable in detecting doses up to the 5th and 6th printed layers until color saturation of the yellow color parameter (b*) was observed on the substrates. Liquid chromatography mass spectrometry was used as a reference method for the colorimetry measurements plotted against the number of printed layers. It was concluded that colorimetry could be used as a quality control tool for detection of different doses. However, optimization of the color addition needs to be done to avoid color saturation within the planned dose interval.

AB - Printing technologies were recently introduced to the pharmaceutical field for manufacturing of drug delivery systems. Printing allows on demand manufacturing of flexible pharmaceutical doses in a personalized manner, which is critical for a successful and safe treatment of patient populations with specific needs, such as children and the elderly, and patients facing multimorbidity. Printing of pharmaceuticals as technique generates new demands on the quality control procedures. For example, rapid quality control is needed as the printing can be done on demand and at the point of care. This study evaluated the potential use of a handheld colorimetry device for quality control of printed doses of vitamin Bs on edible rice and sugar substrates. The structural features of the substrates with and without ink were also compared. A multicomponent ink formulation with vitamin B1, B2, B3, and B6 was developed. Doses (4 cm(2)) were prepared by applying 1-10 layers of yellow ink onto the white substrates using thermal inkjet technology. The colorimetric method was seen to be viable in detecting doses up to the 5th and 6th printed layers until color saturation of the yellow color parameter (b*) was observed on the substrates. Liquid chromatography mass spectrometry was used as a reference method for the colorimetry measurements plotted against the number of printed layers. It was concluded that colorimetry could be used as a quality control tool for detection of different doses. However, optimization of the color addition needs to be done to avoid color saturation within the planned dose interval.

U2 - 10.1208/s12249-016-0620-1

DO - 10.1208/s12249-016-0620-1

M3 - Journal article

VL - 18

SP - 293

EP - 302

JO - A A P S PharmSciTech

JF - A A P S PharmSciTech

SN - 1530-9932

IS - 2

ER -

ID: 168934671