Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffraction

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffraction. / Karjalainen, Milja; Airaksinen, Sari; Rantanen, Jukka; Aaltonen, Jaakko; Yliruusi, Jouko.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 39, No. 1-2, 01.09.2005, p. 27-32.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Karjalainen, M, Airaksinen, S, Rantanen, J, Aaltonen, J & Yliruusi, J 2005, 'Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffraction', Journal of Pharmaceutical and Biomedical Analysis, vol. 39, no. 1-2, pp. 27-32. https://doi.org/10.1016/j.jpba.2005.02.036

APA

Karjalainen, M., Airaksinen, S., Rantanen, J., Aaltonen, J., & Yliruusi, J. (2005). Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffraction. Journal of Pharmaceutical and Biomedical Analysis, 39(1-2), 27-32. https://doi.org/10.1016/j.jpba.2005.02.036

Vancouver

Karjalainen M, Airaksinen S, Rantanen J, Aaltonen J, Yliruusi J. Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffraction. Journal of Pharmaceutical and Biomedical Analysis. 2005 Sep 1;39(1-2):27-32. https://doi.org/10.1016/j.jpba.2005.02.036

Author

Karjalainen, Milja ; Airaksinen, Sari ; Rantanen, Jukka ; Aaltonen, Jaakko ; Yliruusi, Jouko. / Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffraction. In: Journal of Pharmaceutical and Biomedical Analysis. 2005 ; Vol. 39, No. 1-2. pp. 27-32.

Bibtex

@article{c8a522c2333b4056b7535e7e5d887de7,
title = "Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffraction",
abstract = "The aim of this study was to use variable temperature X-ray powder diffraction (VT-XRPD) to understand the solid-state changes in the pharmaceutical materials during heating. The model compounds studied were sulfathiazole, theophylline and nitrofurantoin. This study showed that the polymorph form of sulfathiazole SUTHAZ01 was very stable and SUTHAZ02 changed as a function of temperature to SUTHAZ01. Theophylline monohydrate changed via its metastable form to its anhydrous form during heating and nitrofurantoin monohydrate changed via amorphous form to its anhydrous form during heating. The crystallinity of SUTHAZ01, SUTHAZ02 and theophylline monohydrate were very high and stable. Nitrofurantoin monohydrate was also very crystalline at room temperature but during heating at lower temperatures the crystallinity decreased and started to increase strongly at the temperature where the sample had changed to the anhydrous form. The average crystallite size of sulfathiazole samples varied only a little during heating. The average crystallite size of both theophylline and nitrofurantoin monohydrate decreased during heating. However, the average crystallite size of nitrofurantoin monohydrate returned back to starting size at higher temperatures. These analyses showed that VT-XRPD can be used to effectively characterize polymorphic changes during heating.",
keywords = "Nitrofurantoin, Powder Diffraction, Temperature, Theophylline, X-Ray Diffraction",
author = "Milja Karjalainen and Sari Airaksinen and Jukka Rantanen and Jaakko Aaltonen and Jouko Yliruusi",
year = "2005",
month = "9",
day = "1",
doi = "10.1016/j.jpba.2005.02.036",
language = "English",
volume = "39",
pages = "27--32",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
issn = "0731-7085",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Characterization of polymorphic solid-state changes using variable temperature X-ray powder diffraction

AU - Karjalainen, Milja

AU - Airaksinen, Sari

AU - Rantanen, Jukka

AU - Aaltonen, Jaakko

AU - Yliruusi, Jouko

PY - 2005/9/1

Y1 - 2005/9/1

N2 - The aim of this study was to use variable temperature X-ray powder diffraction (VT-XRPD) to understand the solid-state changes in the pharmaceutical materials during heating. The model compounds studied were sulfathiazole, theophylline and nitrofurantoin. This study showed that the polymorph form of sulfathiazole SUTHAZ01 was very stable and SUTHAZ02 changed as a function of temperature to SUTHAZ01. Theophylline monohydrate changed via its metastable form to its anhydrous form during heating and nitrofurantoin monohydrate changed via amorphous form to its anhydrous form during heating. The crystallinity of SUTHAZ01, SUTHAZ02 and theophylline monohydrate were very high and stable. Nitrofurantoin monohydrate was also very crystalline at room temperature but during heating at lower temperatures the crystallinity decreased and started to increase strongly at the temperature where the sample had changed to the anhydrous form. The average crystallite size of sulfathiazole samples varied only a little during heating. The average crystallite size of both theophylline and nitrofurantoin monohydrate decreased during heating. However, the average crystallite size of nitrofurantoin monohydrate returned back to starting size at higher temperatures. These analyses showed that VT-XRPD can be used to effectively characterize polymorphic changes during heating.

AB - The aim of this study was to use variable temperature X-ray powder diffraction (VT-XRPD) to understand the solid-state changes in the pharmaceutical materials during heating. The model compounds studied were sulfathiazole, theophylline and nitrofurantoin. This study showed that the polymorph form of sulfathiazole SUTHAZ01 was very stable and SUTHAZ02 changed as a function of temperature to SUTHAZ01. Theophylline monohydrate changed via its metastable form to its anhydrous form during heating and nitrofurantoin monohydrate changed via amorphous form to its anhydrous form during heating. The crystallinity of SUTHAZ01, SUTHAZ02 and theophylline monohydrate were very high and stable. Nitrofurantoin monohydrate was also very crystalline at room temperature but during heating at lower temperatures the crystallinity decreased and started to increase strongly at the temperature where the sample had changed to the anhydrous form. The average crystallite size of sulfathiazole samples varied only a little during heating. The average crystallite size of both theophylline and nitrofurantoin monohydrate decreased during heating. However, the average crystallite size of nitrofurantoin monohydrate returned back to starting size at higher temperatures. These analyses showed that VT-XRPD can be used to effectively characterize polymorphic changes during heating.

KW - Nitrofurantoin

KW - Powder Diffraction

KW - Temperature

KW - Theophylline

KW - X-Ray Diffraction

U2 - 10.1016/j.jpba.2005.02.036

DO - 10.1016/j.jpba.2005.02.036

M3 - Journal article

C2 - 16085131

VL - 39

SP - 27

EP - 32

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

SN - 0731-7085

IS - 1-2

ER -

ID: 140622016